Flagyl and Depakene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flagyl (metronidazole) and Depakene (valproic acid). Common drug interactions include abdominal pain upper among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Flagyl and Depakene. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Flagyl?

Flagyl has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 25,897 Flagyl users. Check the latest studies of Flagyl.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

On Jul, 07, 2026

48 people who take Flagyl and Depakene together, and have interactions are studied.

What are the common drug interactions of Flagyl and Depakene, by gender? *:

female:

Abdominal pain upper
Aortic rupture
Blood creatine phosphokinase increased
Blood creatinine increased
Bone marrow failure
Brain abscess
Candida sepsis (candida in blood stream)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Compression fracture (fracture due to pressure caused by injury)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)

male:

Confusional state
Headache (pain in head)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Arrhythmia (irregular heartbeat)
Epistaxis (bleed from the nose)
Erythema (redness of the skin)
Gingival bleeding (bleeding gums)
Haemorrhage subcutaneous (bleeding from skin)
Idiopathic thrombocytopenic purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting)
Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Flagyl and Depakene, by age (0-1 to 60+)? *:

0-1:

Brain damage
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

2-9:

Drug ineffective
Increased bronchial secretion
Arrhythmia (irregular heartbeat)
Epistaxis (bleed from the nose)
Gingival bleeding (bleeding gums)
Haemorrhage subcutaneous (bleeding from skin)
Idiopathic thrombocytopenic purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting)
Platelet disorder
Pneumonia
Pulmonary haemorrhage (acute bleeding from the lung)

10-19:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Erythema (redness of the skin)
Nasopharyngitis (inflammation of the nasopharynx)
Pruritus (severe itching of the skin)
Sinus congestion (blockage of sinus)
Sinusitis (inflammation of sinus)
Wound

20-29:

Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

30-39:

Splenic necrosis (death of most or all of the cells of spleen)
Splenic vein thrombosis (blood clot in splenic vein)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Haematocrit decreased
Infection
Feeling cold
Haemoglobin decreased
Laboratory test abnormal
Neutropenia (an abnormally low number of neutrophils)

40-49:

Confusional state
Headache (pain in head)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Renal failure acute (rapid kidney dysfunction)
Blood potassium increased
Hepatitis acute
Hepatocellular damage (liver damage)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)

50-59:

Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Thrombocytopenia (decrease of platelets in blood)
Tremor (trembling or shaking movements in one or more parts of your body)

60+:

Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Drug level increased
Oedema (fluid collection in tissue)
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)
Abdominal pain upper

What are the existing conditions these people have? *

Gastric Ulcer (stomach ulcer): 4 people, 8.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 8.33%
Insomnia (sleeplessness): 3 people, 6.25%
Infection: 3 people, 6.25%
Diverticular Perforation (serious gastrointestinal condition in which the intestine's walls are perforated): 3 people, 6.25%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 6.25%
Brain Neoplasm Malignant (brain cancer tumour): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Flagyl and Depakene?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously