Flagyl and Ritalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flagyl (metronidazole) and Ritalin (methylphenidate hydrochloride). Common drug interactions include pain among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Flagyl and Ritalin. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Flagyl?

Flagyl has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 25,897 Flagyl users. Check the latest studies of Flagyl.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

98 people who take Flagyl and Ritalin together, and have interactions are studied.

What are the common drug interactions of Flagyl and Ritalin, by gender? *:

female:

Pain
Back pain
Fall
Osteomyelitis (infection of bone)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Cold sweat
Metastases to bone (cancer spreads to bone)
Neuropathy peripheral (surface nerve damage)
Dizziness

male:

Decreased appetite
Fatigue (feeling of tiredness)
Asthenia (weakness)
Febrile neutropenia (fever with reduced white blood cells)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Surgery
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease

What are the common drug interactions of Flagyl and Ritalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Acne cystic (skin problems that cause pimples)
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Bradycardia (abnormally slow heart action)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Conductive deafness (deafness due to a problem in conducting sound waves)
Dry mouth
Hypotension (abnormally low blood pressure)

20-29:

Cold sweat
Cytomegalovirus infection
Gastritis (inflammation of stomach)
Hepatitis (inflammation of the liver)
Insomnia (sleeplessness)
Ulcer
Blood pressure decreased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Febrile neutropenia (fever with reduced white blood cells)
Gastrointestinal toxicity (damage to digestive tract by any substance)

30-39:

Abdominal hernia
Alopecia (absence of hair from areas of the body)
Anxiety
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Body temperature decreased
Bone disorder
Cellulitis (infection under the skin)
Chest pain
Chills (felling of cold)

40-49:

Hyperphagia (an abnormal appetite for food)
Agitation (state of anxiety or nervous excitement)
Body temperature increased
Dizziness
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)
Insomnia (sleeplessness)

50-59:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Chronic kidney disease
Depressed mood
Disturbance in attention
Emotional disorder
Emotional distress
Fear of disease

60+:

Fall
Back pain
Abnormal behaviour
Accident
Aggression
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Anogenital warts
Arrhythmia supraventricular (irregular heartbeat supraventricular origin)
Arteriosclerosis (thickening and hardening of arteries)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 32 people, 32.65%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 19 people, 19.39%
Pain: 11 people, 11.22%
Breast Cancer: 10 people, 10.20%
Headache (pain in head): 9 people, 9.18%
Constipation: 8 people, 8.16%
Metastases To Bone (cancer spreads to bone): 7 people, 7.14%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 7.14%
Neuropathy Peripheral (surface nerve damage): 6 people, 6.12%
Depression: 6 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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