Flector and Metaxalone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flector (diclofenac epolamine) and Metaxalone (metaxalone). Common drug interactions include autonomic nervous system imbalance among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Flector and Metaxalone. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Flector?

Flector has active ingredients of diclofenac epolamine. It is often used in pain. eHealthMe is studying from 5,112 Flector users. Check the latest studies of Flector.

What is Metaxalone?

Metaxalone has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 4,452 Metaxalone users. Check the latest studies of Metaxalone.

On Jul, 13, 2026

27 people who take Flector and Metaxalone together, and have interactions are studied.

Flector and Metaxalone drug interactions.

What are the common drug interactions of Flector and Metaxalone, by gender? *:

female:

Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Behcet's syndrome (involves inflammation of the blood vessels)
Diarrhoea
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Therapeutic response unexpected
Visual impairment
Weight increased
Anxiety

male:

Death
Drug dependence

What are the common drug interactions of Flector and Metaxalone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Behcet's syndrome (involves inflammation of the blood vessels)
Depression
Incoherent (talking in a confused and unclear way)
Weight increased

40-49:

n/a

50-59:

Gait disturbance
General physical health deterioration (weak health status)
Malaise (a feeling of general discomfort or uneasiness)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Photophobia (extreme sensitivity to light)
Abdominal distension
Apathy
Asthenia (weakness)
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Chest discomfort

60+:

Arthralgia (joint pain)
Dysstasia (difficulty in standing)
Irritable bowel syndrome
Neuropathy peripheral (surface nerve damage)
Rash
Respiratory tract infection
Skin irritation
Spinal fracture (fracture in one of vertebrae)
Urinary tract infection
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 37.04%
High Blood Pressure: 8 people, 29.63%
Hypersensitivity: 8 people, 29.63%
Migraine (headache): 8 people, 29.63%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 22.22%
Stress And Anxiety: 6 people, 22.22%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 18.52%
Inflammation: 5 people, 18.52%
Autonomic Nervous System Imbalance (autonomic nervous system is of net equal emphasis): 4 people, 14.81%
Behcet's Syndrome (involves inflammation of the blood vessels): 4 people, 14.81%

* Approximation only. Some reports may have incomplete information.

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