Flexeril and Adcirca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Adcirca (tadalafil). Common drug interactions include abdominal distension among females and oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Adcirca. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

On Jul, 16, 2026

70 people who take Flexeril and Adcirca together, and have interactions are studied.

What are the common drug interactions of Flexeril and Adcirca, by gender? *:

female:

Abdominal distension
Abdominal pain
Abscess (pus)
Acute respiratory failure
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Ascites (accumulation of fluid in the abdominal cavity)
Bladder cancer
Brain neoplasm (tumour of brain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Oedema (fluid collection in tissue)
Weight increased
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Glomerular filtration rate decreased
Hypokinesia (decreased bodily movement)
Hypotension (abnormally low blood pressure)
Insulin-requiring type 2 diabetes mellitus
Limb injury
Lung cancer metastatic (lung cancer spreads to other parts)

What are the common drug interactions of Flexeril and Adcirca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)
Gastric antral vascular ectasia (blood vessels in the lining of the stomach become fragile and become prone to rupture and bleeding)
Gastric disorder (disease of stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Thrombocytopenia (decrease of platelets in blood)

40-49:

Nausea (feeling of having an urge to vomit)
Migraine (headache)
Palpitations (feelings or sensations that your heart is pounding or racing)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Pain
Pain in jaw
Burning sensation
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

50-59:

Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Anxiety
Appetite disorder (abnormal eating habits)
Asthenia (weakness)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deafness
Drug administration error
Fatigue (feeling of tiredness)
Pain in extremity

60+:

Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Eye irritation
Fluid retention (an abnormal accumulation of fluid in the blood)
Flushing (the warm, red condition of human skin)
Hip arthroplasty
Osteoporosis (bones weak and more likely to break)
Oxygen saturation decreased
Pain in extremity
Respiratory tract congestion (blockage on respiratory system)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 49 people, 70.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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