Flexeril and Artane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Artane (trihexyphenidyl hydrochloride). Common drug interactions include vertigo among females and pathological gambling among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Artane. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Artane?

Artane has active ingredients of trihexyphenidyl hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,619 Artane users. Check the latest studies of Artane.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

20 people who take Flexeril and Artane together, and have interactions are studied.

What are the common drug interactions of Flexeril and Artane, by gender? *:

female:

Vertigo
Vomiting
Hallucination, auditory (perceiving sounds without auditory stimulus)
Headache (pain in head)
Hallucination, visual (seeing things that aren't there)
Abdominal discomfort
Abdominal distension
Activities of daily living impaired
Acute left ventricular failure (heart attack)
Acute respiratory failure

male:

Pathological gambling
Asthenia (weakness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Anxiety
Drug ineffective
Emotional distress
Hypersexuality
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Suicidal ideation
Anger

What are the common drug interactions of Flexeril and Artane, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Abdominal distension
Activities of daily living impaired
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anxiety
Asthenia (weakness)
Bruxism (habitual grinding of the teeth, typically during sleep)
Deformity (disfigurement)
Depression
Dyskinesia (abnormality or impairment of voluntary movement)

30-39:

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Gastritis alkaline reflux (inflammation of the gastric mucosa believed to be caused by irritating factors that reflux from the intestine into the stomach)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Headache (pain in head)
Oesophageal perforation (hole in oesophagus)
Sedation

40-49:

n/a

50-59:

Asthenia (weakness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Flatulence (flatus expelled through the anus)
Non-cardiac chest pain
Respiratory tract congestion (blockage on respiratory system)
Activities of daily living impaired
Acute left ventricular failure (heart attack)
Acute respiratory failure
Agitation (state of anxiety or nervous excitement)
Anxiety

60+:

Anger

What are the existing conditions these people have? *

Depression: 4 people, 20.00%
Bipolar Disorder (mood disorder): 4 people, 20.00%
Pain: 4 people, 20.00%
High Blood Cholesterol: 3 people, 15.00%
Diabetes: 3 people, 15.00%
Quit Smoking: 2 people, 10.00%
High Blood Pressure: 2 people, 10.00%
Muscle Rigidity (muscle stiffness): 2 people, 10.00%
Psychotic Disorder: 2 people, 10.00%
Anaemia (lack of blood): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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