Flexeril and Asacol hd drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Asacol hd (mesalamine). Common drug interactions include malaise among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Asacol hd. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Asacol hd?

Asacol hd has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 985 Asacol hd users. Check the latest studies of Asacol hd.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

18 people who take Flexeril and Asacol hd together, and have interactions are studied.

Flexeril and Asacol hd drug interactions.

What are the common drug interactions of Flexeril and Asacol Hd, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Nerve injury
Pneumonia
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Rash
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Asthenia (weakness)
Fatigue (feeling of tiredness)

male:

Constipation
Drug ineffective

What are the common drug interactions of Flexeril and Asacol Hd, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthenia (weakness)
Drug ineffective
Fatigue (feeling of tiredness)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

40-49:

n/a

50-59:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Fungal skin infection
Injection site induration
Injection site pain
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Pain

60+:

Fall
Pyrexia (fever)
Drug hypersensitivity
Weight decreased
Ageusia (loss of taste functions of the tongue)
Ankle fracture
Asthenia (weakness)
Brain injury
Chest pain
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 44.44%
Apnea (temporary absence or cessation of breathing): 5 people, 27.78%
Pain: 3 people, 16.67%
Depression: 3 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.11%
Colitis (inflammation of colon): 1 person, 5.56%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 5.56%
Dyspnea (difficult or laboured breathing): 1 person, 5.56%
Drowsiness: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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