Flexeril and Cephulac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Cephulac (lactulose). Common drug interactions include abnormal behaviour among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Cephulac. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Cephulac?

Cephulac has active ingredients of lactulose. eHealthMe is studying from 136 Cephulac users. Check the latest studies of Cephulac.

On Jul, 18, 2026

11 people who take Flexeril and Cephulac together, and have interactions are studied.

Flexeril and Cephulac drug interactions.

What are the common drug interactions of Flexeril and Cephulac, by gender? *:

female:

Abnormal behaviour
Balance disorder
Cardiac disorder
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus inadequate control
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysarthria (speech disorder)
Dystonia (abnormal muscle tone)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Endocarditis (inflammation in heart muscle)

male:

Dehydration (dryness resulting from the removal of water)
Post procedural haematoma (post procedural clotting of blood)
Cardiac failure congestive
Chest pain
Coagulopathy (blood's ability to clot is impaired)
Confusional state
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Death
Delirium (wild excitement)
Depression

What are the common drug interactions of Flexeril and Cephulac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abnormal behaviour
Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Balance disorder
Blood glucose increased
Cardiac disorder

60+:

Post procedural haematoma (post procedural clotting of blood)
Cardiac failure congestive
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 27.27%
Kidney Stones: 2 people, 18.18%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
Gout (uric acid crystals building up in the body): 2 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%
Enlarged Prostate: 2 people, 18.18%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 18.18%
Prostate Cancer: 1 person, 9.09%
Insomnia (sleeplessness): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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