Flexeril and Daliresp drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Daliresp (roflumilast). Common drug interactions include weight decreased among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Daliresp. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Daliresp?

Daliresp has active ingredients of roflumilast. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 4,722 Daliresp users. Check the latest studies of Daliresp.

On Jul, 21, 2026

53 people who take Flexeril and Daliresp together, and have interactions are studied.

Flexeril and Daliresp drug interactions.

What are the common drug interactions of Flexeril and Daliresp, by gender? *:

female:

Weight decreased
Weight increased
Wheezing (a high-pitched whistling sound made while you breath)
Ankylosing spondylitis (type of arthritis affecting the spine)
Ataxia (loss of full control of bodily movements)
Bone pain
Constipation
Dysphonia (speech disorder attributable to a disorder of phonation)
Eating disorder
Eye pain

male:

Weight decreased
Dyspnoea (difficult or laboured respiration)
Adverse drug reaction
Anaemia (lack of blood)
Anxiety
Arthralgia (joint pain)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac arrest

What are the common drug interactions of Flexeril and Daliresp, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Ataxia (loss of full control of bodily movements)
Blood pressure increased
Chest discomfort
Constipation
Cough
Diarrhoea
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Eating disorder

50-59:

Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Erectile dysfunction
Heart rate irregular
Hypertension (high blood pressure)
Impaired gastric emptying
Increased viscosity of bronchial secretion
Insomnia (sleeplessness)
Joint swelling
Lacrimation increased

60+:

Weight decreased
Dyspnoea (difficult or laboured respiration)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hypotension (abnormally low blood pressure)
Leukocytosis (increased white blood cells)
Oedema peripheral (superficial swelling)
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Pulmonary necrosis (death of a small area of lung)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Pain: 10 people, 18.87%
High Blood Pressure: 8 people, 15.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 15.09%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 11.32%
High Blood Cholesterol: 6 people, 11.32%
Depression: 5 people, 9.43%
Gastric Disorder (disease of stomach): 5 people, 9.43%
Type 2 Diabetes: 4 people, 7.55%
Thyroid Diseases: 4 people, 7.55%
Stress And Anxiety: 4 people, 7.55%

* Approximation only. Some reports may have incomplete information.

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