Flexeril and Dulera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Dulera (mometasone furoate; formoterol fumarate). Common drug interactions include gallbladder enlargement among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Dulera. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Dulera?

Dulera has active ingredients of mometasone furoate; formoterol fumarate. It is often used in asthma. eHealthMe is studying from 4,801 Dulera users. Check the latest studies of Dulera.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

37 people who take Flexeril and Dulera together, and have interactions are studied.

What are the common drug interactions of Flexeril and Dulera, by gender? *:

female:

Gallbladder enlargement
Gastritis (inflammation of stomach)
Gastrointestinal infection (infection of stomach and intestine)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Haematemesis (vomiting of blood)
Hepatic steatosis (fatty liver disease)
Humerus fracture (injury to the upper arm bone)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersensitivity

male:

Arthralgia (joint pain)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Insomnia (sleeplessness)
Jaw disorder (jaw disease)
Tobacco user
Abdominal pain
Blood cholesterol increased
Chills (felling of cold)
Diabetes mellitus inadequate control

What are the common drug interactions of Flexeril and Dulera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Alopecia (absence of hair from areas of the body)
Sepsis (a severe blood infection that can lead to organ failure and death)
Spinal cord injury
Thrombosis (formation of a blood clot inside a blood vessel)
Viral diarrhoea

40-49:

Abdominal pain
Arthralgia (joint pain)
Chills (felling of cold)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Rash

50-59:

Vomiting
Waist circumference increased
Wheezing (a high-pitched whistling sound made while you breath)
Drug ineffective
Weight increased
Pneumonia
Vitamin b12 deficiency
Arthralgia (joint pain)
Attention deficit/hyperactivity disorder
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)

60+:

Malaise (a feeling of general discomfort or uneasiness)
Oral infection
Essential hypertension (primary hypertension)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Interstitial lung disease
Laryngospasm (an uncontrolled/involuntary muscular contraction of larynx)
Memory impairment

What are the existing conditions these people have? *

Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 13 people, 35.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 24.32%
Stress And Anxiety: 6 people, 16.22%
Pain: 5 people, 13.51%
High Blood Cholesterol: 5 people, 13.51%
Depression: 4 people, 10.81%
Hypersensitivity: 4 people, 10.81%
High Blood Pressure: 4 people, 10.81%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 8.11%
Quit Smoking: 3 people, 8.11%

* Approximation only. Some reports may have incomplete information.

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