Flexeril and Femhrt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Femhrt (ethinyl estradiol; norethindrone acetate). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Femhrt. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Femhrt?

Femhrt has active ingredients of ethinyl estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 2,025 Femhrt users. Check the latest studies of Femhrt.

On Jul, 13, 2026

14 people who take Flexeril and Femhrt together, and have interactions are studied.

What are the common drug interactions of Flexeril and Femhrt, by gender? *:

female:

Drug ineffective
Arthropathy
Sinusitis (inflammation of sinus)
Hypophagia (reduced food intake)
Abnormal dreams
Activities of daily living impaired
Asthenia (weakness)
Blood creatinine increased
Blood pressure increased
Breast cancer

male:

n/a

What are the common drug interactions of Flexeril and Femhrt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cyst (a closed sac)
Hypersensitivity
Hypertension (high blood pressure)

50-59:

Oedema peripheral (superficial swelling)
Blood creatinine increased
Blood pressure increased
Breast cancer
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Chest pain
Cough
Dizziness
Dizziness postural
Gout (uric acid crystals building up in the body)

60+:

Arthropathy
Blood cholesterol increased
Fibrin d dimer increased
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hip arthroplasty
Hyperthyroidism (over activity of the thyroid gland)
Oestrogen deficiency (lack of estrogens)
Paranasal sinus hypersecretion
Pneumonia
Polyarthritis (arthritis which involves 5 or more joints simultaneously)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 21.43%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 21.43%
Depression: 2 people, 14.29%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 14.29%
Neuralgia (pain in one or more nerves): 2 people, 14.29%
Sleep Disorder: 1 person, 7.14%
Insomnia (sleeplessness): 1 person, 7.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%
High Blood Cholesterol: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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