Flexeril and Gabitril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Gabitril (tiagabine hydrochloride). Common drug interactions include nervousness among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Gabitril. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Gabitril?

Gabitril has active ingredients of tiagabine hydrochloride. It is often used in epilepsy. eHealthMe is studying from 2,230 Gabitril users. Check the latest studies of Gabitril.

On Jul, 26, 2026

40 people who take Flexeril and Gabitril together, and have interactions are studied.

Flexeril and Gabitril drug interactions.

What are the common drug interactions of Flexeril and Gabitril, by gender? *:

female:

Nervousness
Renal injury (kidney injury)
Spinal disorder (disease of spine a back bone)
Tinnitus (a ringing in the ears)
Type 2 diabetes mellitus
Violence-related symptom
Abdominal pain upper
Activities of daily living impaired
Acute psychosis (period of mentally unstable behaviour)
Ageusia (loss of taste functions of the tongue)

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoaesthesia (reduced sense of touch or sensation)
Hyperglycaemia (high blood sugar)
Memory impairment
Panic attack
Renal disorder (kidney disease)
Tooth extraction
Visual acuity reduced (reduced clearness of vision)
Cough
Dry mouth

What are the common drug interactions of Flexeril and Gabitril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Device failure
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hyperglycaemia (high blood sugar)
Blood pressure decreased
Blood pressure increased
Candidiasis (candidiasis or thrush is a fungal infection)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dizziness
Dysuria (painful or difficult urination)
Hypoaesthesia (reduced sense of touch or sensation)

40-49:

Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)
Hypoacusis (loss of hearing)
Hypoaesthesia (reduced sense of touch or sensation)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Incoherent (talking in a confused and unclear way)
Inflammation
Intervertebral disc protrusion (spinal disc protrusion)
Joint sprain (an injury to joint surrounding flexible fibres)
Loss of consciousness

50-59:

Swelling
Activities of daily living impaired
Acute psychosis (period of mentally unstable behaviour)
Ageusia (loss of taste functions of the tongue)
Aggression
Anger
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Blood pressure increased
Chronic kidney disease
Confusional state

60+:

Cough
Dry mouth
Loss of consciousness
Swelling
Syncope (loss of consciousness with an inability to maintain postural tone)
Type 2 diabetes mellitus
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Fatigue (feeling of tiredness)
Agitation (state of anxiety or nervous excitement)
Delirium (wild excitement)

What are the existing conditions these people have? *

Pain: 10 people, 25.00%
Sleep Disorder: 5 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 10.00%
Depression: 4 people, 10.00%
Stress And Anxiety: 3 people, 7.50%
Muscle Rigidity (muscle stiffness): 3 people, 7.50%
Joint Pain: 3 people, 7.50%
High Blood Pressure: 3 people, 7.50%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 5.00%
Oesophageal Candidiasis (fungal infection of oesophagus): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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