Flexeril and Isentress drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Isentress (raltegravir potassium). Common drug interactions include hand fracture among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Isentress. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Isentress?

Isentress has active ingredients of raltegravir potassium. It is often used in hiv infection. eHealthMe is studying from 16,529 Isentress users. Check the latest studies of Isentress.

On Jul, 10, 2026

42 people who take Flexeril and Isentress together, and have interactions are studied.

Flexeril and Isentress drug interactions.

What are the common drug interactions of Flexeril and Isentress, by gender? *:

female:

Hand fracture
Joint injury
Proteinuria (presence of protein in the urine)
Renal injury (kidney injury)
Subcutaneous abscess
Weight decreased
Pain
Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

male:

Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Renal impairment (severely reduced kidney function)
Quality of life decreased
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Osteopenia (a condition where bone mineral density is lower than normal)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Renal failure (kidney dysfunction)

What are the common drug interactions of Flexeril and Isentress, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Emotional distress
Lethargy (tiredness)
Pain
Quality of life decreased
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Bone density decreased
Bone loss
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Depression
Emotional distress
Fracture
Hand fracture

40-49:

Chronic kidney disease
Pain
Osteonecrosis (death of bone)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Renal impairment (severely reduced kidney function)
Blood creatinine increased
Bone density decreased
Decreased activity

50-59:

Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Osteoporosis (bones weak and more likely to break)
Bone density decreased
Chronic kidney disease
Fatigue (feeling of tiredness)
Depression
Decreased activity

60+:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Hand fracture
Ill-defined disorder
Immune system disorder
Joint injury
Osteoporosis (bones weak and more likely to break)
Protein urine present
Renal impairment (severely reduced kidney function)
Skeletal injury (bone and supporting muscle injury)

What are the existing conditions these people have? *

Pain: 11 people, 26.19%
Depression: 8 people, 19.05%
High Blood Pressure: 8 people, 19.05%
Asthma: 7 people, 16.67%
Prostatomegaly (enlargement of the prostate): 6 people, 14.29%
Bacterial Infection: 6 people, 14.29%
Stress And Anxiety: 6 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 14.29%
Chest Pain: 5 people, 11.90%
Constipation: 5 people, 11.90%

* Approximation only. Some reports may have incomplete information.

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