Flexeril and Lidex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Lidex (fluocinonide). Common drug interactions include fatigue among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Lidex. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Lidex?

Lidex has active ingredients of fluocinonide. eHealthMe is studying from 1,039 Lidex users. Check the latest studies of Lidex.

On Jul, 15, 2026

38 people who take Flexeril and Lidex together, and have interactions are studied.

What are the common drug interactions of Flexeril and Lidex, by gender? *:

female:

Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Gout (uric acid crystals building up in the body)
Heart rate irregular
Hospitalisation
Hyperaesthesia
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperlipidaemia (presence of excess lipids in the blood)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Back disorder
Headache (pain in head)
Migraine (headache)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Pancreatitis (inflammation of pancreas)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aphasia (damage to the parts of the brain that control language)
Balance disorder

What are the common drug interactions of Flexeril and Lidex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Appendicitis (inflammation of the appendix)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

30-39:

Malaise (a feeling of general discomfort or uneasiness)

40-49:

Chronic kidney disease
Dehydration (dryness resulting from the removal of water)
Gastric ulcer perforation (stomach hole due to ulcer)
Mobility decreased (ability to move is reduced)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Renal failure (kidney dysfunction)
Spinal pain (pain in spine)

50-59:

Death
Drug dependence
Emotional distress
Fall
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hyperaesthesia
Intervertebral disc disorder (spinal disc disorder)
Lumbar radiculopathy (radicular pain in the low back and legs)
Muscular weakness (muscle weakness)
Peroneal nerve palsy

60+:

Pain in extremity
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Stress
Back disorder
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Migraine (headache)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)

What are the existing conditions these people have? *

Pain: 19 people, 50.00%
Constipation: 7 people, 18.42%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 18.42%
Migraine (headache): 7 people, 18.42%
Nausea (feeling of having an urge to vomit): 7 people, 18.42%
High Blood Pressure: 6 people, 15.79%
General Physical Health Deterioration (weak health status): 4 people, 10.53%
Hypersensitivity: 4 people, 10.53%
Nausea And Vomiting: 4 people, 10.53%
Blood Pressure Abnormal: 4 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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