Flexeril and Mefenamic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Mefenamic acid (mefenamic acid). Common drug interactions include malaise among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Mefenamic acid. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Mefenamic acid?

Mefenamic acid has active ingredients of mefenamic acid. It is often used in painful menstrual periods. eHealthMe is studying from 4,844 Mefenamic acid users. Check the latest studies of Mefenamic acid.

On Jul, 07, 2026

32 people who take Flexeril and Mefenamic acid together, and have interactions are studied.

Flexeril and Mefenamic acid drug interactions.

What are the common drug interactions of Flexeril and Mefenamic Acid, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Chest discomfort
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastric cancer (stomach cancer)
Pain
Pancreatic carcinoma (pancreatic cancer)
Surgery
Abdominal discomfort
Brain injury
Cardiovascular disorder (heart diseases)

male:

Fatigue (feeling of tiredness)
Abscess limb (limb infection)
Cellulitis (infection under the skin)
Cyst (a closed sac)
Drug ineffective
Pyrexia (fever)
Skin ulcer
Hidradenitis (chronic disease of a type of sweat gland)
Pruritus (severe itching of the skin)

What are the common drug interactions of Flexeril and Mefenamic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abscess limb (limb infection)
Cellulitis (infection under the skin)
Cyst (a closed sac)
Drug ineffective
Fatigue (feeling of tiredness)
Pyrexia (fever)
Skin ulcer
Hidradenitis (chronic disease of a type of sweat gland)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)

40-49:

Brain injury
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Surgery
Blood glucose decreased
Cellulitis (infection under the skin)
Dry eye (lack of adequate tears)
Hysterectomy
Influenza
Nausea (feeling of having an urge to vomit)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)

50-59:

Injection site reaction

60+:

Oedema peripheral (superficial swelling)
Malaise (a feeling of general discomfort or uneasiness)
Hypoaesthesia (reduced sense of touch or sensation)
Joint swelling
Pain
Peripheral coldness
Skin disorder (skin disease)
Hospitalisation
Insomnia (sleeplessness)
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 28.12%
Stress And Anxiety: 8 people, 25.00%
Pain: 8 people, 25.00%
High Blood Pressure: 8 people, 25.00%
Sleep Disorder: 7 people, 21.88%
High Blood Cholesterol: 7 people, 21.88%
Hypotonia (low muscle tone): 6 people, 18.75%
Erection Problems: 6 people, 18.75%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 15.62%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Flexeril and Mefenamic acid?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously