Flexeril and Microzide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Microzide (hydrochlorothiazide). Common drug interactions include depression among females and cataract among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Microzide. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Microzide?

Microzide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 994 Microzide users. Check the latest studies of Microzide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

41 people who take Flexeril and Microzide together, and have interactions are studied.

Flexeril and Microzide drug interactions.

What are the common drug interactions of Flexeril and Microzide, by gender? *:

female:

Depression
Diabetes mellitus inadequate control
Diarrhoea
Drug effect decreased
Drug intolerance (drug sensitivity)
Ejection fraction decreased (systolic heart failure)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Feeling jittery
Gangrene (body tissue dies)
Haemangioma of spleen (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in spleen)

male:

Cataract (clouding of the lens inside the eye)
Fatigue (feeling of tiredness)
Mobility decreased (ability to move is reduced)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Pain in extremity
Rib fracture
Tendon rupture (tear of tendon)

What are the common drug interactions of Flexeril and Microzide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug ineffective

40-49:

Coronary artery stenosis (narrowing of coronary artery)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphoria (generalized dissatisfaction with life)
Facet joint syndrome (problem with movement of the facet joints of the spine)
Facial bones fracture (bone fracture of face)
Fall
Hyperaesthesia
Intervertebral disc degeneration (spinal disc degeneration)
Osteoporosis (bones weak and more likely to break)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

50-59:

Pain
Arthropathy
Bone density decreased
Bone loss
Dizziness
Emotional distress
Foot fracture
Mobility decreased (ability to move is reduced)
Nausea (feeling of having an urge to vomit)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

60+:

Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Hip fracture
Interstitial granulomatous dermatitis (inflammation of the skin)
Pain
Pneumonia bacterial (pneumonia associated with bacterial infection)
Pneumonia viral
Abdominal discomfort
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Back disorder

What are the existing conditions these people have? *

Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 24.39%
Back Pain: 9 people, 21.95%
Stress And Anxiety: 8 people, 19.51%
Pain: 7 people, 17.07%
Joint Pain: 7 people, 17.07%
Nausea (feeling of having an urge to vomit): 6 people, 14.63%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 12.20%
Itching: 5 people, 12.20%
Neuralgia (pain in one or more nerves): 4 people, 9.76%
Nausea And Vomiting: 4 people, 9.76%

* Approximation only. Some reports may have incomplete information.

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