Flexeril and Milk thistle drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Milk thistle (milk thistle). Common drug interactions include alanine aminotransferase increased among females and rash among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Milk thistle. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Milk thistle?

Milk thistle has active ingredients of milk thistle. It is often used in fatty liver. eHealthMe is studying from 5,057 Milk thistle users. Check the latest studies of Milk thistle.

On Jul, 13, 2026

72 people who take Flexeril and Milk thistle together, and have interactions are studied.

Flexeril and Milk thistle drug interactions.

What are the common drug interactions of Flexeril and Milk Thistle, by gender? *:

female:

Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)
Aspartate aminotransferase increased
Blood albumin decreased
Blood alkaline phosphatase increased
Blood glucose increased
Blood thyroid stimulating hormone increased
Bone disorder
C-reactive protein increased
Calcium deficiency (lack of calcium)

male:

Rash
Diarrhoea
Arthropathy
Back disorder
Headache (pain in head)
Migraine (headache)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Abdominal pain
Allergic sinusitis
Blood pressure increased

What are the common drug interactions of Flexeril and Milk Thistle, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthropathy
Blood pressure increased
Dizziness
Fatigue (feeling of tiredness)
Fear
Lethargy (tiredness)
Loss of consciousness
Nightmare (unpleasant dream)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

40-49:

Androgen deficiency
Calcium deficiency (lack of calcium)
Emotional distress
Feeling hot
Flushing (the warm, red condition of human skin)
Foot fracture
Neuropathic arthropathy (a progressive destruction of bone and joints)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Ulna fracture (fracture inside bone)

50-59:

Tongue disorder (disease of tongue)
Chest pain
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Epstein-barr virus infection
Fall
Head injury
Road traffic accident
Tremor (trembling or shaking movements in one or more parts of your body)
Blindness
Anaemia (lack of blood)

60+:

Diarrhoea
Back disorder
Blood alkaline phosphatase increased
Blood glucose increased
Blood thyroid stimulating hormone increased
C-reactive protein increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)

What are the existing conditions these people have? *

Pain: 15 people, 20.83%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 13.89%
Depression: 9 people, 12.50%
Asthma: 8 people, 11.11%
Diabetes: 8 people, 11.11%
Insomnia (sleeplessness): 7 people, 9.72%
Back Pain: 6 people, 8.33%
Migraine (headache): 6 people, 8.33%
Neuralgia (pain in one or more nerves): 5 people, 6.94%
Nausea (feeling of having an urge to vomit): 5 people, 6.94%

* Approximation only. Some reports may have incomplete information.

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