Flexeril and Odefsey drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Odefsey (emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate). Common drug interactions include anhedonia among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Odefsey. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Odefsey?

Odefsey has active ingredients of emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 4,605 Odefsey users. Check the latest studies of Odefsey.

On Jul, 21, 2026

16 people who take Flexeril and Odefsey together, and have interactions are studied.

What are the common drug interactions of Flexeril and Odefsey, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Depression
Emotional distress
Pain
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Sleep disorder

male:

Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Depression
Disturbance in attention
Dizziness
Dysphemia (stammering or stuttering)
Executive dysfunction
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)

What are the common drug interactions of Flexeril and Odefsey, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bone density decreased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone pain
Emotional distress
Foot fracture
Hand fracture
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Vitamin d deficiency

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Depression
Emotional distress
Hand fracture
Ligament rupture (tear in ligament)
Neck pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Foot fracture
Nephropathy (damage to or disease of a kidney)
Pain
Renal failure (kidney dysfunction)
Multiple fractures

60+:

Abnormal dreams
Anxiety
Memory impairment
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Visual impairment
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Blood creatinine increased

What are the existing conditions these people have? *

Prostate Cancer: 3 people, 18.75%
Pain: 1 person, 6.25%
Nausea (feeling of having an urge to vomit): 1 person, 6.25%
Lipodystrophy Acquired (a regional loss of subcutaneous adipose tissue which usually starts in the face, extends downward acquired): 1 person, 6.25%
Inflammation: 1 person, 6.25%
Hypersensitivity: 1 person, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%
Fungal Infection: 1 person, 6.25%
Depression: 1 person, 6.25%
Bacterial Infection: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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