Flexeril and Olanzapine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Olanzapine (olanzapine). Common drug interactions include chronic kidney disease among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Olanzapine. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Olanzapine?

Olanzapine has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 69,242 Olanzapine users. Check the latest studies of Olanzapine.

On Jul, 21, 2026

76 people who take Flexeril and Olanzapine together, and have interactions are studied.

Flexeril and Olanzapine drug interactions.

What are the common drug interactions of Flexeril and Olanzapine, by gender? *:

female:

Chronic kidney disease
Insomnia (sleeplessness)
Headache (pain in head)
Somnolence (a state of near-sleep, a strong desire for sleep)
Asthenia (weakness)
Atrophy (wasting away of a part of the body)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Joint effusion (presence of extra fluid in joint covering)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoporosis (bones weak and more likely to break)

male:

Nausea (feeling of having an urge to vomit)
Chronic kidney disease
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Balance disorder
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral atrophy (decrement in size of brain)
Foot fracture
Hyperglycaemia (high blood sugar)
Nephropathy (damage to or disease of a kidney)
Speech disorder

What are the common drug interactions of Flexeril and Olanzapine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Arthralgia (joint pain)
Dissociation
Gait disturbance
Headache (pain in head)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Panic attack
Priapism (prolonged and painful erection that can last from several hours up to a few days)
Sensory disturbance (sense disturbance)

30-39:

Blood bilirubin unconjugated increased
Incoherent (talking in a confused and unclear way)
Malaise (a feeling of general discomfort or uneasiness)
Paralysis
Somnolence (a state of near-sleep, a strong desire for sleep)
Victim of sexual abuse

40-49:

Dysphagia (a condition in which swallowing is difficult or painful)
Gastric disorder (disease of stomach)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperlipidaemia (presence of excess lipids in the blood)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Obesity (having too much body fat)
Surgery
Type 2 diabetes mellitus

50-59:

Pain
Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Emotional distress
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Balance disorder

60+:

Chronic kidney disease
Fall
Hot flush (sudden feelings of heat)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Nausea (feeling of having an urge to vomit)
Neck pain
Nephrogenic anaemia (anaemia due to kidney disease)
Night sweats (sweating in night)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 11 people, 14.47%
Sleep Disorder: 9 people, 11.84%
Pain: 9 people, 11.84%
Stress And Anxiety: 7 people, 9.21%
High Blood Pressure: 7 people, 9.21%
Depression: 7 people, 9.21%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.89%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 5 people, 6.58%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 5.26%
Nausea (feeling of having an urge to vomit): 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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