Flexeril and Ozempic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Ozempic (semaglutide). Common drug interactions include renal failure among females and cellulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Ozempic. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,761 Ozempic users. Check the latest studies of Ozempic.

On Aug, 06, 2026

35 people who take Flexeril and Ozempic together, and have interactions are studied.

What are the common drug interactions of Flexeril and Ozempic, by gender? *:

female:

Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Road traffic accident
Scleroderma (hard skin)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Skin hyperpigmentation (disorders affect the colour of your skin)
Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

male:

Cellulitis (infection under the skin)
Perirectal abscess
Arthralgia (joint pain)
Arthropathy
Cartilage injury
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic lymphocytic leukaemia stage 0 (blood cell cancer with no enlargement of the lymph nodes, spleen, or liver, and with near normal red blood cell and platelet counts)
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Flexeril and Ozempic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pulmonary hypertension (increase in blood pressure in the lung artery)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Scleroderma (hard skin)
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Skin hyperpigmentation (disorders affect the colour of your skin)
Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Thrombocytopenia (decrease of platelets in blood)
Thrombotic thrombocytopenic purpura (a rare blood disorder characterized by clotting in small blood vessels of the body)

30-39:

n/a

40-49:

Abdominal pain upper
Decreased appetite
Headache (pain in head)
Ill-defined disorder
Nausea (feeling of having an urge to vomit)
Visual impairment
Vomiting

50-59:

Cellulitis (infection under the skin)
Perirectal abscess
Renal impairment (severely reduced kidney function)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Abdominal pain upper
Acidosis (build-up of carbon dioxide in the blood)
Anaemia (lack of blood)
Anion gap increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease

60+:

Foot fracture
Malaise (a feeling of general discomfort or uneasiness)
Cartilage injury
Chronic kidney disease
Depression
Emotional distress
Fall
Hand fracture
Head injury
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 20.00%
High Blood Pressure: 7 people, 20.00%
Diabetes: 7 people, 20.00%
Type 2 Diabetes: 7 people, 20.00%
Pain: 6 people, 17.14%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 11.43%
Gout (uric acid crystals building up in the body): 4 people, 11.43%
High Blood Cholesterol: 4 people, 11.43%
Cyclitis (inflammation of the ciliary body (eye)): 3 people, 8.57%
Diabetes Insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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