Flexeril and Trental drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Trental (pentoxifylline). Common drug interactions include arterial stenosis among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Trental. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Trental?

Trental has active ingredients of pentoxifylline. eHealthMe is studying from 3,511 Trental users. Check the latest studies of Trental.

On Jul, 16, 2026

38 people who take Flexeril and Trental together, and have interactions are studied.

What are the common drug interactions of Flexeril and Trental, by gender? *:

female:

Arterial stenosis (abnormal narrowing of the aortic valve in the heart)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Balance disorder
Blood creatinine increased
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiomyopathy (weakening of the heart muscle)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Cerebral infarction (less blood supply to brain resulting tissue damage)

male:

Fall
Drug ineffective
Asthma
Blood creatine kinase low
Blood glucose increased
Blood in stool
Blood pressure decreased
Blood urea increased
Cardiac murmur functional (heart sound due to physiological condition outside the heart)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

What are the common drug interactions of Flexeril and Trental, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Erythema (redness of the skin)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)
Throat tightness
Urticaria (rash of round, red welts on the skin that itch intensely)

20-29:

Fall
Loss of consciousness
Overdose
Abscess (pus)
Abscess neck (neck abscesses)
Asthma
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pharyngeal neoplasm (pharyngeal tumour)
Postoperative wound infection

30-39:

Urticaria (rash of round, red welts on the skin that itch intensely)
Insomnia (sleeplessness)
Pruritus (severe itching of the skin)
Scratch
Drug hypersensitivity
Pain

40-49:

Bladder disorder
Cardiac disorder
Chest pain
General symptom
Ovarian cancer (cancer of ovary)
Peripheral vascular disorder
Rectal haemorrhage (bleeding from anus)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Road traffic accident
Abdominal pain

50-59:

Arteriosclerosis (thickening and hardening of arteries)
Blood cholesterol increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dyspnoea (difficult or laboured respiration)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Hand fracture
Hepatic cyst
Herpes simplex (herpes simplex is a common viral infection)
Intraductal papilloma of breast (tiny wart-like growth in breast tissue)

60+:

Death
Drug ineffective
Blood creatine kinase low
Blood glucose increased
Blood in stool
Blood pressure decreased
Blood urea increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac murmur functional (heart sound due to physiological condition outside the heart)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 13.16%
Thyroid Diseases: 3 people, 7.89%
Heart Disease: 3 people, 7.89%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 7.89%
Asthma: 3 people, 7.89%
Osteoporosis (bones weak and more likely to break): 3 people, 7.89%
Stress And Anxiety: 3 people, 7.89%
Arrhythmias (irregular heartbeat): 2 people, 5.26%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 5.26%
Bipolar Disorder (mood disorder): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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