Flexeril and Vascepa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Vascepa (icosapent ethyl). Common drug interactions include arthralgia among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Vascepa. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Vascepa?

Vascepa has active ingredients of icosapent ethyl. It is often used in high blood cholesterol. eHealthMe is studying from 5,894 Vascepa users. Check the latest studies of Vascepa.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

21 people who take Flexeril and Vascepa together, and have interactions are studied.

What are the common drug interactions of Flexeril and Vascepa, by gender? *:

female:

Arthralgia (joint pain)
Asthenia (weakness)
Fatigue (feeling of tiredness)
Gait disturbance
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Confusional state
Constipation
Cough
Depression
Disturbance in attention

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Food allergy
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Leukocytosis (increased white blood cells)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nephrogenic anaemia (anaemia due to kidney disease)
Orchitis (inflammation of the testes)
Rash

What are the common drug interactions of Flexeril and Vascepa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abscess limb (limb infection)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Orchitis (inflammation of the testes)
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection

30-39:

n/a

40-49:

Abdominal discomfort
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cellulitis (infection under the skin)
Decreased activity
Dysgeusia (disorder of the sense of taste)
Dysstasia (difficulty in standing)
Emotional distress
Eructation (release of gas from the digestive tract)
Fatigue (feeling of tiredness)

50-59:

Dysgeusia (disorder of the sense of taste)
Retching (strong involuntary effort to vomit)

60+:

Arthralgia (joint pain)
Asthenia (weakness)
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)
Gait disturbance
Hyperglycaemia (high blood sugar)
Hyperhidrosis (abnormally increased sweating)
Influenza
Insomnia (sleeplessness)
Joint swelling

What are the existing conditions these people have? *

Pain: 12 people, 57.14%
High Blood Pressure: 10 people, 47.62%
Constipation: 6 people, 28.57%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 23.81%
Weakness: 5 people, 23.81%
Neuralgia (pain in one or more nerves): 5 people, 23.81%
Abdominal Discomfort: 5 people, 23.81%
Back Pain: 4 people, 19.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 19.05%
Diabetes: 4 people, 19.05%

* Approximation only. Some reports may have incomplete information.

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