Flexeril and Ziagen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Ziagen (abacavir sulfate). Common drug interactions include gingival swelling among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Ziagen. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Ziagen?

Ziagen has active ingredients of abacavir sulfate. It is often used in hiv infection. eHealthMe is studying from 7,626 Ziagen users. Check the latest studies of Ziagen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

28 people who take Flexeril and Ziagen together, and have interactions are studied.

What are the common drug interactions of Flexeril and Ziagen, by gender? *:

female:

Gingival swelling (gums swelling)
Haematuria (presence of blood in urine)
Hand fracture
Humerus fracture (injury to the upper arm bone)
Intervertebral disc degeneration (spinal disc degeneration)
Loose tooth
Multiple fractures
Nephrolithiasis (calculi in the kidneys)
Oropharyngeal plaque (hard deposit on oropharynx)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Mobility decreased (ability to move is reduced)
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain in extremity
Pruritus (severe itching of the skin)
Quality of life decreased
Renal failure acute (rapid kidney dysfunction)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Flexeril and Ziagen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alcohol poisoning
Anogenital warts
Atelectasis (partial or complete collapse of the lung)
Bipolar disorder (mood disorder)
Blood hiv rna increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Fracture
Kidney infection
Renal failure (kidney dysfunction)

40-49:

Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Cyst (a closed sac)
Depression
Emotional distress
Foot fracture
Injection site haemorrhage (bleeding from injection site)
Injection site reaction
Pain

50-59:

Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Osteoporosis (bones weak and more likely to break)
Bone density decreased
Chronic kidney disease
Gait disturbance
Osteopenia (a condition where bone mineral density is lower than normal)
Renal impairment (severely reduced kidney function)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Emotional distress
Fatigue (feeling of tiredness)
Mobility decreased (ability to move is reduced)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Quality of life decreased

What are the existing conditions these people have? *

High Blood Cholesterol: 8 people, 28.57%
Pain: 7 people, 25.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 21.43%
Inflammation: 5 people, 17.86%
Asthma: 4 people, 14.29%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 14.29%
Peripheral Neuropathy (damage to nerves of the peripheral nervous system): 3 people, 10.71%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 10.71%
Flatulence (flatus expelled through the anus): 2 people, 7.14%
Heart Rate Irregular: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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