Flexeril and Zyvox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Zyvox (linezolid). Common drug interactions include platelet count increased among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Zyvox. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Zyvox?

Zyvox has active ingredients of linezolid. It is often used in mrsa infection. eHealthMe is studying from 9,399 Zyvox users. Check the latest studies of Zyvox.

On Jul, 18, 2026

65 people who take Flexeril and Zyvox together, and have interactions are studied.

What are the common drug interactions of Flexeril and Zyvox, by gender? *:

female:

Platelet count increased
Vitreous detachment (a condition of the eye in which the vitreous humour separates from the retina)
Osteonecrosis of jaw (death of bone of jaw)
Pyrexia (fever)
Device failure
Hypoaesthesia (reduced sense of touch or sensation)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Scab (a hard coating on the skin formed during the wound healing)
Dry mouth

male:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Cardiac murmur (an heart sound in valve abnormality)
Perirectal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Anxiety
Dizziness
Drug ineffective
Drug toxicity
Endocarditis (inflammation in heart muscle)

What are the common drug interactions of Flexeril and Zyvox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Emotional distress
General physical health deterioration (weak health status)
Iliac artery thrombosis (obstruction of a blood vessel by a blood clot in iliac artery)
Injury
Pain
Peripheral ischaemia (impaired circulation to an extremity)
Abscess (pus)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

30-39:

n/a

40-49:

Injection site necrosis (death of body tissue at injection site)
Staphylococcal infection (an infection with staphylococcus bacteria)
Vomiting
Dizziness
Drug ineffective
Headache (pain in head)
Ill-defined disorder
Injection site pain
Injection site ulcer
Morton's neuralgia (severe pain on the ball of the foot and at the base of toe)

50-59:

Swelling face
Dental caries
Escherichia infection (bacterial infection by escherichia coli)
Osteitis (a general term for inflammation of bone)
Tooth abscess (pus formation in tooth)
Bone disorder
Bone pain
Osteopenia (a condition where bone mineral density is lower than normal)
Wound infection staphylococcal
Appendicitis (inflammation of the appendix)

60+:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Pyrexia (fever)
Renal failure acute (rapid kidney dysfunction)
Respiratory alkalosis (elevated blood ph due to excess breathing)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Anxiety
Arthralgia (joint pain)
Depression
Drug hypersensitivity
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 30 people, 46.15%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 29 people, 44.62%
Thrombocytopenia (decrease of platelets in blood): 11 people, 16.92%
Neoplasm Malignant (cancer tumour): 10 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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