Flolan and Allopurinol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flolan (epoprostenol sodium) and Allopurinol (allopurinol). Common drug interactions include fluid retention among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Flolan and Allopurinol. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Flolan?

Flolan has active ingredients of epoprostenol sodium. eHealthMe is studying from 10,067 Flolan users. Check the latest studies of Flolan.

What is Allopurinol?

Allopurinol has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 190,868 Allopurinol users. Check the latest studies of Allopurinol.

On Jul, 20, 2026

64 people who take Flolan and Allopurinol together, and have interactions are studied.

Flolan and Allopurinol drug interactions.

What are the common drug interactions of Flolan and Allopurinol, by gender? *:

female:

Fluid retention (an abnormal accumulation of fluid in the blood)
Renal impairment (severely reduced kidney function)
Weight increased
Blood iron decreased
Haematocrit decreased
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Ascites (accumulation of fluid in the abdominal cavity)
Blood creatinine increased
Disease progression

male:

Diarrhoea
Weight increased
General physical health deterioration (weak health status)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site induration
Infusion site infection
Infusion site inflammation
Infusion site pain
Infusion site swelling
Infusion site warmth

What are the common drug interactions of Flolan and Allopurinol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Ascites (accumulation of fluid in the abdominal cavity)
Sudden death unexplained
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Cardiac disorder
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Chest pain
Pericardial effusion (fluid around the heart)
Right ventricular failure (right half of the heart fails to work)
Tricuspid valve incompetence (inefficient heart valve)

10-19:

Cardiogenic shock (inadequate circulation of blood)
Oliguria (not enough urine)
Pain
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Aspartate aminotransferase increased
Blood bilirubin increased
Blood lactate dehydrogenase increased
Blood pressure decreased
Hypotension (abnormally low blood pressure)

20-29:

Haematocrit increased
Antinuclear factor positive
Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Colitis ulcerative (inflammation of colon with ulcer)
Drug hypersensitivity
Haematochezia (passage of stools containing blood)
Haemorrhage (bleeding)
Interstitial pneumonia (lung disease characterized by progressive scarring of both lungs)
Leukocytosis (increased white blood cells)
Lung transplant

30-39:

Abscess neck (neck abscesses)
Renal impairment (severely reduced kidney function)
Weight increased
Infusion site erythema (reddening of the skin at infusion site)
Infusion site induration
Infusion site infection
Infusion site inflammation
Infusion site pain
Infusion site swelling
Infusion site warmth

40-49:

Urticaria (rash of round, red welts on the skin that itch intensely)
Oropharyngeal blistering (blister of oropharynx)
Dyspnoea (difficult or laboured respiration)
Oral mucosal blistering (mouth ulcer)
White blood cell count increased
Oedema peripheral (superficial swelling)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cardiac failure
Diarrhoea
Drug effect decreased

50-59:

Anaemia (lack of blood)
Angioplasty
C-reactive protein increased
Cardiac failure
Death
Electrolyte imbalance
Euphoric mood (excessively happy but may become angry or irritable)
Flushing (the warm, red condition of human skin)
Iatrogenic injury (iatrogenic injury is a form of medical error)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

60+:

Fatigue (feeling of tiredness)
Oedema (fluid collection in tissue)
Blood creatinine increased
Disease progression
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Renal impairment (severely reduced kidney function)
Right ventricular failure (right half of the heart fails to work)
Sepsis (a severe blood infection that can lead to organ failure and death)
Weight increased

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 39 people, 60.94%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 13 people, 20.31%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 7 people, 10.94%
Right Ventricular Failure (right half of the heart fails to work): 6 people, 9.38%
Injection Site Pain: 4 people, 6.25%
High Blood Pressure: 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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