Flolan and Lanoxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flolan (epoprostenol sodium) and Lanoxin (digoxin). Common drug interactions include hypotension among females and fluid retention among males.

The phase IV clinical study analyzes what interactions people have when they take Flolan and Lanoxin. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Flolan?

Flolan has active ingredients of epoprostenol sodium. eHealthMe is studying from 10,067 Flolan users. Check the latest studies of Flolan.

What is Lanoxin?

Lanoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 21,852 Lanoxin users. Check the latest studies of Lanoxin.

On Aug, 05, 2026

57 people who take Flolan and Lanoxin together, and have interactions are studied.

What are the common drug interactions of Flolan and Lanoxin, by gender? *:

female:

Hypotension (abnormally low blood pressure)
Diarrhoea
Fatigue (feeling of tiredness)
Abdominal pain
Chest pain
Anaemia (lack of blood)
Constipation
Oedema (fluid collection in tissue)
Dizziness
Oxygen saturation decreased

male:

Fluid retention (an abnormal accumulation of fluid in the blood)
Cardiac failure
Pulmonary hypertension (increase in blood pressure in the lung artery)

What are the common drug interactions of Flolan and Lanoxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pulmonary hypertension (increase in blood pressure in the lung artery)
Nausea (feeling of having an urge to vomit)
Vomiting
Catheter site related reaction
Drug eruption (adverse drug reaction of the skin)
Hypotension (abnormally low blood pressure)
Rash
Skin lesion
Staphylococcal infection (an infection with staphylococcus bacteria)
Superinfection

30-39:

Anaemia (lack of blood)
Arrhythmia (irregular heartbeat)
Fatigue (feeling of tiredness)
Thrombocytopenia (decrease of platelets in blood)
Ventricular fibrillation (abnormally irregular heart rhythm)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Weight decreased
Abdominal pain
Angina pectoris (chest pain due to ischemia of the heart muscle)
Apnoea (suspension of external breathing)

40-49:

Oedema (fluid collection in tissue)
Oesophageal ulcer (ulcer of oesophagus)
Oesophagitis (inflammation of oesophagus)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
Protein total decreased
Pulmonary embolism (blockage of the main artery of the lung)
Renal impairment (severely reduced kidney function)

50-59:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Diarrhoea
Abdominal pain upper
Biliary dilatation
Chest pain
Dehydration (dryness resulting from the removal of water)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)

60+:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Weight decreased
Back pain
Catheter site haemorrhage (bleeding at catheter site)
Dizziness
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Headache (pain in head)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 25 people, 43.86%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 16 people, 28.07%
Pulmonary Hypertension Primary (increase in blood pressure in the lung artery with no cause): 13 people, 22.81%

* Approximation only. Some reports may have incomplete information.

Do you take Flolan and Lanoxin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously