Floxin and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Floxin (ofloxacin) and Metformin (metformin hydrochloride). Common drug interactions include fibromyalgia among females and diabetes mellitus inadequate control among males.

The phase IV clinical study analyzes what interactions people have when they take Floxin and Metformin. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Floxin?

Floxin has active ingredients of ofloxacin. eHealthMe is studying from 1,737 Floxin users. Check the latest studies of Floxin.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

On Jul, 12, 2026

31 people who take Floxin and Metformin together, and have interactions are studied.

What are the common drug interactions of Floxin and Metformin, by gender? *:

female:

Fibromyalgia (a long-term condition which causes pain all over the body)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mania (a state of abnormally elevated or irritable mood)
Nephrogenic anaemia (anaemia due to kidney disease)
Neuropathy peripheral (surface nerve damage)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Drug hypersensitivity
Tremor (trembling or shaking movements in one or more parts of your body)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

male:

Diabetes mellitus inadequate control
Renal failure acute (rapid kidney dysfunction)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Syncope (loss of consciousness with an inability to maintain postural tone)
Nausea (feeling of having an urge to vomit)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac murmur (an heart sound in valve abnormality)
Cardiomegaly (increased size of heart than normal)
Constipation

What are the common drug interactions of Floxin and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Fibromyalgia (a long-term condition which causes pain all over the body)
Mania (a state of abnormally elevated or irritable mood)
Neuropathy peripheral (surface nerve damage)
Renal failure (kidney dysfunction)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Chronic kidney disease
Chest pain
Headache (pain in head)

40-49:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Hyperglycaemia (high blood sugar)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic kidney disease
Diabetes mellitus inadequate control
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hepatitis (inflammation of the liver)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

50-59:

Blood potassium increased
Blood sodium decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic obstructive airways disease
Cirrhosis alcoholic (chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue caused by alcoholism)
Confusion
Death
Diabetic nephropathy (diabetic kidney disease)
Diarrhoea
Eating disorder

60+:

Pain
Asthenia (weakness)
Emotional distress
Hyperhidrosis (abnormally increased sweating)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Palpitations (feelings or sensations that your heart is pounding or racing)
Syncope (loss of consciousness with an inability to maintain postural tone)
Anxiety
Burning sensation
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the existing conditions these people have? *

Depression: 8 people, 25.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 22.58%
High Blood Cholesterol: 6 people, 19.35%
High Blood Pressure: 5 people, 16.13%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 5 people, 16.13%
Stress And Anxiety: 5 people, 16.13%
Anaemia (lack of blood): 5 people, 16.13%
Osteopenia (a condition where bone mineral density is lower than normal): 4 people, 12.90%
Sleep Disorder: 4 people, 12.90%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 12.90%

* Approximation only. Some reports may have incomplete information.

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