Fluconazole and Tykerb drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluconazole (fluconazole) and Tykerb (lapatinib ditosylate). Common drug interactions include bone disorder among females and depressed level of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Fluconazole and Tykerb. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

On Jul, 13, 2026

45 people who take Fluconazole and Tykerb together, and have interactions are studied.

Fluconazole and Tykerb drug interactions.

What are the common drug interactions of Fluconazole and Tykerb, by gender? *:

female:

Bone disorder
Dehydration (dryness resulting from the removal of water)
Dizziness
Metastases to central nervous system (cancer spreads to central nervous system)
Vision blurred
Abdominal pain upper
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Gait disturbance

male:

Depressed level of consciousness
Fatigue (feeling of tiredness)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Death
Drug ineffective
Ill-defined disorder
Malignant neoplasm progression (cancer tumour came back)
Metastasis (spreadable cancer to other organ from origin)
Metastatic carcinoma of the bladder (cancer types can spread to the bladder from other place)

What are the common drug interactions of Fluconazole and Tykerb, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Rash

50-59:

Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Rib fracture
Sensitivity of teeth
Ear congestion
Hypoaesthesia (reduced sense of touch or sensation)
Osteonecrosis of jaw (death of bone of jaw)
Purulent discharge (discharge that contains pus)
Neoplasm recurrence (reoccurrence of tumour)
Radiation skin injury
Bone density decreased

60+:

Diarrhoea
Performance status decreased
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Skin toxicity (skin damage due to toxin/poison)
Arthralgia (joint pain)
Rehabilitation therapy
Dehydration (dryness resulting from the removal of water)
Dysphagia (a condition in which swallowing is difficult or painful)
Febrile neutropenia (fever with reduced white blood cells)
Hypokalaemia (low potassium)

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 19 people, 42.22%
High Blood Pressure: 7 people, 15.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 15.56%
Thrombosis (formation of a blood clot inside a blood vessel): 6 people, 13.33%
Skin Toxicity (skin damage due to toxin/poison): 4 people, 8.89%
Breast Cancer Metastatic: 4 people, 8.89%
Nausea (feeling of having an urge to vomit): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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