Fludara and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fludara (fludarabine phosphate) and Zoloft (sertraline hydrochloride). Common drug interactions include headache among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Fludara and Zoloft. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Fludara?

Fludara has active ingredients of fludarabine phosphate. eHealthMe is studying from 46,686 Fludara users. Check the latest studies of Fludara.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,801 Zoloft users. Check the latest studies of Zoloft.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

71 people who take Fludara and Zoloft together, and have interactions are studied.

What are the common drug interactions of Fludara and Zoloft, by gender? *:

female:

Headache (pain in head)
Asthenia (weakness)
Contusion (a type of hematoma of tissue in which capillaries)
Alanine aminotransferase increased
Balance disorder
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cerebral haemorrhage (bleeding within the brain)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Epistaxis (bleed from the nose)
Haemorrhage (bleeding)

male:

Headache (pain in head)
Tremor (trembling or shaking movements in one or more parts of your body)
Muscular weakness (muscle weakness)
Speech disorder
Alanine aminotransferase increased
Aspartate aminotransferase increased
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Fatigue (feeling of tiredness)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Abdominal pain

What are the common drug interactions of Fludara and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Febrile neutropenia (fever with reduced white blood cells)

10-19:

Pyrexia (fever)
Mydriasis (a dilation of the pupil)
Aspartate aminotransferase increased
Fatigue (feeling of tiredness)
Blood bilirubin increased
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Alanine aminotransferase increased
Confusional state
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)

20-29:

n/a

30-39:

n/a

40-49:

Cerebellar ataxia (loss of coordination)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral atrophy (decrement in size of brain)
Neuropathy peripheral (surface nerve damage)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Balance disorder
Gait disturbance
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Muscular weakness (muscle weakness)

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)
Sialoadenitis (inflammation of a salivary gland)
Subendocardial ischaemia
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Thrombocytopenia (decrease of platelets in blood)
Viral infection
Vomiting
Neutropenia (an abnormally low number of neutrophils)
Anaemia (lack of blood)
Rash

60+:

Renal failure (kidney dysfunction)
Confusional state
Abdominal pain
Dyspnoea (difficult or laboured respiration)
Fall
Haemoglobin decreased
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Anaemia (lack of blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacterial infection

What are the existing conditions these people have? *

Pain: 17 people, 23.94%
Fever: 15 people, 21.13%
Nausea (feeling of having an urge to vomit): 14 people, 19.72%
Constipation: 14 people, 19.72%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 14 people, 19.72%
Nausea And Vomiting: 13 people, 18.31%
B-Cell Type Acute Leukaemia (cancer of the white blood cells): 12 people, 16.90%
Stress And Anxiety: 7 people, 9.86%
Asthma: 5 people, 7.04%
Weakness: 4 people, 5.63%

* Approximation only. Some reports may have incomplete information.

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