Fluoxetine and Accutane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluoxetine (fluoxetine hydrochloride) and Accutane (isotretinoin). Common drug interactions include anaemia among females and inflammatory bowel disease among males.

The phase IV clinical study analyzes what interactions people have when they take Fluoxetine and Accutane. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,823 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

On Jul, 10, 2026

48 people who take Fluoxetine and Accutane together, and have interactions are studied.

Fluoxetine and Accutane drug interactions.

What are the common drug interactions of Fluoxetine and Accutane, by gender? *:

female:

Anaemia (lack of blood)
Blood pressure decreased
Blood triglycerides increased
Chest pain
Diplopia (double vision)
Gastric perforation (hole in stomach)
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)
Pneumonia
Suicidal ideation

male:

Inflammatory bowel disease
Colitis ulcerative (inflammation of colon with ulcer)
Arthralgia (joint pain)
Cough
Gastrointestinal injury (injury to gastrointestinal tract)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Lip dry
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Abdominal pain
Abnormal behaviour

What are the common drug interactions of Fluoxetine and Accutane, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dry skin
Inflammatory bowel disease
Irritable bowel syndrome
Abnormal behaviour
Aggression
Blood triglycerides increased
Blunted affect (lack of emotional reactivity)
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Cheilitis (infection of lips)
Completed suicide (act of taking one's own life)

20-29:

Hyperhidrosis (abnormally increased sweating)
Pain
Pain in extremity
Attention deficit/hyperactivity disorder
Gastrointestinal hypomotility (less activity of the intestinal tract)
Intestinal obstruction
Abdominal pain
Abdominal tenderness
Abnormal dreams
Acute myocardial infarction (acute heart attack)

30-39:

Colitis ulcerative (inflammation of colon with ulcer)
Dry skin
Inflammatory bowel disease
Abdominal pain
Anal fissure
Arthralgia (joint pain)
Back pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Colitis (inflammation of colon)
Confusional state

40-49:

Choroidal effusion (fluid collection in vascular layer of eye that nourishes retina)
Dry skin
Epistaxis (bleed from the nose)
Irritable bowel syndrome
Myopia (difficult to see objects that are far away)
Overdose
Suicide attempt

50-59:

Infusion site bruising
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Intestinal obstruction
Irritable bowel syndrome
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Lip dry
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Micturition urgency (urgency to pass the urine)
Muscular weakness (muscle weakness)
Pelvic abscess

60+:

Inflammatory bowel disease
Colitis ulcerative (inflammation of colon with ulcer)
Intestinal haemorrhage (bleeding from intestine)
Myalgia (muscle pain)
Vision blurred
Vocal cord disorder
Gastrointestinal injury (injury to gastrointestinal tract)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Lip dry
Urinary incontinence (inability to control the flow of urine and involuntary urination)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 10 people, 20.83%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 10.42%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 8.33%
Birth Control: 4 people, 8.33%
High Blood Pressure: 3 people, 6.25%
Affective Disorder (mental disorder): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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