Fluoxetine and Afinitor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluoxetine (fluoxetine hydrochloride) and Afinitor (everolimus). Common drug interactions include bone pain among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Fluoxetine and Afinitor. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,823 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Afinitor?

Afinitor has active ingredients of everolimus. It is often used in breast cancer metastatic. eHealthMe is studying from 41,680 Afinitor users. Check the latest studies of Afinitor.

On Jul, 11, 2026

81 people who take Fluoxetine and Afinitor together, and have interactions are studied.

Fluoxetine and Afinitor drug interactions.

What are the common drug interactions of Fluoxetine and Afinitor, by gender? *:

female:

Bone pain
Tremor (trembling or shaking movements in one or more parts of your body)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Arthralgia (joint pain)
Hypoaesthesia (reduced sense of touch or sensation)
Inflammation
Myalgia (muscle pain)
Oral mucosal blistering (mouth ulcer)
Vertigo
Death

male:

Diarrhoea
Pyrexia (fever)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fall
Haematoma (collection of blood outside the blood vessels)
Hyperglycaemia (high blood sugar)
Influenza
Injection site pain
Metastases to liver (cancer spreads to liver)
Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Fluoxetine and Afinitor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cough
Pneumonia

20-29:

Abnormal behaviour
Aphthous stomatitis (mouth ulcer)
Blood cholesterol increased
Chest pain
Complex partial seizures (epileptic seizure)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fatigue (feeling of tiredness)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Oropharyngeal pain
Upper-airway cough syndrome

30-39:

Acne (skin problems that cause pimples)
Mouth ulceration (mouth ulcers)
Abdominal discomfort
Blood pressure increased
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Diarrhoea
Dry skin
Headache (pain in head)
Kidney infection
Lip dry

40-49:

Arthralgia (joint pain)
Malaise (a feeling of general discomfort or uneasiness)
Malignant neoplasm progression (cancer tumour came back)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blindness
Bone pain
Dizziness
Hypoaesthesia (reduced sense of touch or sensation)
Inflammation
Lymphatic obstruction (blockage in lymphatic duct)

50-59:

Anal fissure
Ascites (accumulation of fluid in the abdominal cavity)
Back pain
Dizziness
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Fluid retention (an abnormal accumulation of fluid in the blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Headache (pain in head)
Hypertension (high blood pressure)

60+:

Blood potassium decreased
Pyrexia (fever)
Fall
Haematoma (collection of blood outside the blood vessels)
Hyperglycaemia (high blood sugar)
Influenza
Injection site pain
Malignant neoplasm progression (cancer tumour came back)
Metastases to liver (cancer spreads to liver)
Nasopharyngitis (inflammation of the nasopharynx)

What are the existing conditions these people have? *

Breast Cancer: 15 people, 18.52%
Renal Cell Carcinoma (a kidney cancer): 13 people, 16.05%
Pancreatic Neuroendocrine Tumor: 9 people, 11.11%
Angiomyolipoma (most common benign tumour of the kidney): 9 people, 11.11%
Neuroendocrine Tumor: 7 people, 8.64%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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