Fluoxetine and Climara drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluoxetine (fluoxetine hydrochloride) and Climara (estradiol). Common drug interactions include asthma among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Fluoxetine and Climara. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,823 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

On Jul, 10, 2026

30 people who take Fluoxetine and Climara together, and have interactions are studied.

Fluoxetine and Climara drug interactions.

What are the common drug interactions of Fluoxetine and Climara, by gender? *:

female:

Asthma
Dehydration (dryness resulting from the removal of water)
Fall
Hypotension (abnormally low blood pressure)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Dyspnoea (difficult or laboured respiration)
Gastritis (inflammation of stomach)
Back pain
Face injury
Accident at work

male:

Anaemia (lack of blood)
Emotional distress
Fear
Injury
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)

What are the common drug interactions of Fluoxetine and Climara, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Back pain
Hypersensitivity
Inflammation
Photosensitivity reaction
Pruritus (severe itching of the skin)
Systemic lupus erythematosus rash (an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue and causes the rashes)

50-59:

Breast cancer female
Fear
Injury
Anaemia (lack of blood)
Emotional distress
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)

60+:

Breast cancer female
Asthma
Hot flush (sudden feelings of heat)
Nasopharyngitis (inflammation of the nasopharynx)
Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tooth fracture
Dehydration (dryness resulting from the removal of water)
Hypotension (abnormally low blood pressure)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)

What are the existing conditions these people have? *

Stress And Anxiety: 10 people, 33.33%
Menopausal Symptoms: 10 people, 33.33%
High Blood Pressure: 7 people, 23.33%
Initial Insomnia (feeling of inadequate or poor-quality sleep): 6 people, 20.00%
High Blood Cholesterol: 4 people, 13.33%
Retinopathy Proliferative (a condition in which very small blood vessels grow from the surface of the retina and damages retina): 3 people, 10.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 10.00%
Insomnia (sleeplessness): 3 people, 10.00%
Hot Flush (sudden feelings of heat): 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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