Fluoxetine and Cobamamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluoxetine (fluoxetine hydrochloride) and Cobamamide (dibencozide). Common drug interactions include asthma among females and blood pressure systolic increased among males.

The phase IV clinical study analyzes what interactions people have when they take Fluoxetine and Cobamamide. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,823 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Cobamamide?

Cobamamide has active ingredients of dibencozide. eHealthMe is studying from 1,046 Cobamamide users. Check the latest studies of Cobamamide.



On Jul, 14, 2026

13 people who take Fluoxetine and Cobamamide together, and have interactions are studied.

Fluoxetine and Cobamamide drug interactions.

What are the common drug interactions of Fluoxetine and Cobamamide, by gender? *:

female:

  1. Asthma
  2. Bone pain
  3. Fall
  4. Hypoaesthesia (reduced sense of touch or sensation)
  5. Influenza
  6. Joint stiffness
  7. Nasal discharge discolouration (change in colour of nasal discharge)
  8. Rhinorrhoea (watery mucus discharge from the nose)
  9. Therapeutic response unexpected
  10. Ulcer

male:

  1. Blood pressure systolic increased
  2. Spinal disorder (disease of spine a back bone)
  3. Asthma
  4. Chest pain
  5. Colonoscopy
  6. Drug ineffective
  7. Oral herpes (viral infection of mouth)
  8. Pain

What are the common drug interactions of Fluoxetine and Cobamamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  2. Pain

40-49:

  1. Pain

50-59:

  1. Arthralgia (joint pain)
  2. Asthma
  3. Bone pain
  4. Fall
  5. Hypoaesthesia (reduced sense of touch or sensation)
  6. Influenza
  7. Joint stiffness
  8. Nasal discharge discolouration (change in colour of nasal discharge)
  9. Rhinorrhoea (watery mucus discharge from the nose)
  10. Therapeutic response unexpected

60+:

  1. Blood pressure systolic increased
  2. Oral pain
  3. Spinal disorder (disease of spine a back bone)
  4. Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
  5. Asthma
  6. Chest pain
  7. Colonoscopy
  8. Drug ineffective
  9. Oral herpes (viral infection of mouth)

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 61.54%
  2. Pain: 3 people, 23.08%
  3. Nervousness: 3 people, 23.08%
  4. Hypersensitivity: 3 people, 23.08%
  5. High Blood Pressure: 3 people, 23.08%
  6. Diplegia (paralysis of corresponding parts on both sides of the body): 3 people, 23.08%
  7. Diabetes: 3 people, 23.08%
  8. Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 23.08%
  9. The Flu (the flu is caused by an influenza virus): 2 people, 15.38%
  10. Nasal Discharge Discoloration: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Fluoxetine and Cobamamide?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Fluoxetine and Cobamamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fluoxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Cobamamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Fluoxetine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cobamamide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride and dibencozide (the active ingredients of Fluoxetine and Cobamamide, respectively), and Fluoxetine and Cobamamide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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