Fluoxetine and Niacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluoxetine (fluoxetine hydrochloride) and Niacin (niacin). Common drug interactions include tinnitus among females and renal impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Fluoxetine and Niacin. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,823 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Niacin?

Niacin has active ingredients of niacin. It is often used in high blood cholesterol. eHealthMe is studying from 9,008 Niacin users. Check the latest studies of Niacin.

On Jul, 20, 2026

74 people who take Fluoxetine and Niacin together, and have interactions are studied.

Fluoxetine and Niacin drug interactions.

What are the common drug interactions of Fluoxetine and Niacin, by gender? *:

female:

Tinnitus (a ringing in the ears)
Blindness
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Headache (pain in head)
Neck pain
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Postnasal drip
Spinal osteoarthritis (joint cartilage loss in spine)
Ear pain
Laryngitis (inflammation of the larynx)

male:

Renal impairment (severely reduced kidney function)
Chronic kidney disease
Electrocardiogram qt prolonged
Fall
Gait disturbance
Injury
Nausea (feeling of having an urge to vomit)
Pancreatitis acute (sudden inflammation of pancreas)
Pyrexia (fever)
Abdominal pain

What are the common drug interactions of Fluoxetine and Niacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

30-39:

Confusional state
Disease recurrence
Eye infection
Infection
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Respiratory tract infection
Synovial cyst (cyst of joint filled with synovial fluid)
Unevaluable reaction
Vaginal infection

40-49:

Chest pain
Dyspnoea (difficult or laboured respiration)
Abdominal pain
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Injection site erythema (redness at injection site)
Injection site pain
Injection site swelling
Injection site warmth
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)

50-59:

Inflammation
Influenza
Infusion site haemorrhage (bleeding from infusion site)
Infusion site pain
Malaise (a feeling of general discomfort or uneasiness)
Pain
Productive cough
Pyrexia (fever)
Rhinorrhoea (watery mucus discharge from the nose)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

60+:

Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Sensation of foreign body
Tinnitus (a ringing in the ears)
Blindness
Dizziness
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Headache (pain in head)
Neck pain
Nervous system disorder (a general class of medical conditions affecting the nervous system)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 24.32%
Type 2 Diabetes: 8 people, 10.81%
High Blood Pressure: 8 people, 10.81%
Pain: 7 people, 9.46%
Diabetes: 6 people, 8.11%
Stress And Anxiety: 5 people, 6.76%
Bipolar Disorder (mood disorder): 5 people, 6.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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