Fluoxetine and Tpn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluoxetine (fluoxetine hydrochloride) and Tpn (niacinamide; pyridoxine hydrochloride; tyrosine). Common drug interactions include constipation among females and fungaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Fluoxetine and Tpn. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,824 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Tpn?

Tpn has active ingredients of niacinamide; pyridoxine hydrochloride; tyrosine. eHealthMe is studying from 1,581 Tpn users. Check the latest studies of Tpn.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

21 people who take Fluoxetine and Tpn together, and have interactions are studied.

What are the common drug interactions of Fluoxetine and Tpn, by gender? *:

female:

Constipation
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Disease progression
Drooling (drop saliva uncontrollably from the mouth)
Enterocutaneous fistula
Eructation (release of gas from the digestive tract)
Fatigue (feeling of tiredness)
Diarrhoea
Weight decreased

male:

Fungaemia (fungi circulate in the blood)
Bacteraemia (presence of bacteria in the blood)
Hepatotoxicity (chemical-driven liver damage)
Hypoaesthesia (reduced sense of touch or sensation)
Hyporeflexia (a condition of below normal or absent reflexes)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Malignant neoplasm progression (cancer tumour came back)
Memory impairment
Mesenteric artery thrombosis (blood clot in mesenteric artery)

What are the common drug interactions of Fluoxetine and Tpn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Fungaemia (fungi circulate in the blood)
Bacteraemia (presence of bacteria in the blood)
Device related infection

30-39:

Alanine aminotransferase increased
Ascites (accumulation of fluid in the abdominal cavity)
Aspartate aminotransferase increased
Blood albumin decreased
Blood alkaline phosphatase increased
Blood calcium decreased
Blood chloride decreased
Blood chromogranin a increased
Blood creatinine decreased
Blood glucose increased

40-49:

n/a

50-59:

Cough
Asthenia (weakness)
Asthma
Bronchopneumopathy
Concomitant disease progression (progress in accompanying disease)
Decreased appetite
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Feeding disorder (when children refuse to eat certain food groups)

60+:

Abdominal distension
Abdominal pain
Oedema peripheral (superficial swelling)
Weight decreased
Weight increased
Change of bowel habit
Infrequent bowel movements
Abdominal abscess (collection of pus in abdomen)
Abdominal discomfort
Abdominal tenderness

What are the existing conditions these people have? *

Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 15 people, 71.43%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 14.29%
Gallstones (stone formation by bile component): 3 people, 14.29%
Diarrhea: 3 people, 14.29%
Rickets (softening of bones): 2 people, 9.52%
Inflammatory Bowel Disease: 2 people, 9.52%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 9.52%
Bleeding Disorders: 2 people, 9.52%
Bacterascites (bacterial infection of ascetic fluid): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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