Fluoxetine and Ziac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluoxetine (fluoxetine hydrochloride) and Ziac (bisoprolol fumarate; hydrochlorothiazide). Common drug interactions include respiratory distress among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Fluoxetine and Ziac. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,823 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

On Jul, 20, 2026

35 people who take Fluoxetine and Ziac together, and have interactions are studied.

What are the common drug interactions of Fluoxetine and Ziac, by gender? *:

female:

Respiratory distress (difficulty in breathing)
Somnolence (a state of near-sleep, a strong desire for sleep)
Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Back pain
Malaise (a feeling of general discomfort or uneasiness)
Arthralgia (joint pain)
Blood potassium decreased
Decreased appetite

male:

Cardiac disorder
Death
Upper respiratory tract infection
Dyspnoea (difficult or laboured respiration)
Heart valve incompetence (heart's valves do not work correctly)
Lower respiratory tract infection
Lymph gland infection
Lymphadenopathy (disease or enlargement of lymph nodes)
Middle ear effusion (fluid in middle ear)
Neck mass (mass in neck)

What are the common drug interactions of Fluoxetine and Ziac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Therapeutic response unexpected
Decreased appetite
Malaise (a feeling of general discomfort or uneasiness)
Ageusia (loss of taste functions of the tongue)
Anosmia (partial or complete loss of the sense of smell)
Throat irritation

40-49:

Cardiac disorder
Cardiac failure
Heart valve incompetence (heart's valves do not work correctly)
Lymph gland infection
Lymphadenopathy (disease or enlargement of lymph nodes)
Middle ear effusion (fluid in middle ear)
Neck mass (mass in neck)
Nephrolithiasis (calculi in the kidneys)
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory failure (inadequate gas exchange by the respiratory system)

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Alopecia (absence of hair from areas of the body)
Cardiac disorder
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death
Dizziness
Dyspnoea (difficult or laboured respiration)

60+:

Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Back pain
Sweating increased (excess sweating)
Vomiting
Abnormal behaviour
Acquired oesophageal web (structural abnormalities in the oesophagus)
Alopecia (absence of hair from areas of the body)
Altered state of consciousness (altered state of mind)
Anogenital warts
Arrhythmia (irregular heartbeat)

What are the existing conditions these people have? *

Pain: 15 people, 42.86%
Diabetes: 6 people, 17.14%
Small Cell Lung Cancer Stage Unspecified (lung cancer in unknown stage): 5 people, 14.29%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 14.29%
Muscle Aches (muscle pain): 3 people, 8.57%
Joint Pain: 3 people, 8.57%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 8.57%
Hypersensitivity: 3 people, 8.57%
High Blood Cholesterol: 3 people, 8.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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