Focalin xr and Abilify drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Focalin xr (dexmethylphenidate hydrochloride) and Abilify (aripiprazole). Common drug interactions include lower limb fracture among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Focalin xr and Abilify. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Focalin xr?

Focalin xr has active ingredients of dexmethylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 2,159 Focalin xr users. Check the latest studies of Focalin xr.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,454 Abilify users. Check the latest studies of Abilify.

On Jul, 15, 2026

43 people who take Focalin xr and Abilify together, and have interactions are studied.

Focalin xr and Abilify drug interactions.

What are the common drug interactions of Focalin Xr and Abilify, by gender? *:

female:

Lower limb fracture
Migraine (headache)
Mobility decreased (ability to move is reduced)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Panic reaction
Restlessness (not able to rest)
Road traffic accident
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Spinal fracture (fracture in one of vertebrae)

male:

Drug ineffective
Dizziness
Emotional distress
Gynaecomastia (enlargement of the gland tissue of the male breast)
Nausea (feeling of having an urge to vomit)
Restlessness (not able to rest)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vomiting
Weight increased
Tardive dyskinesia (a disorder that involves involuntary movements)

What are the common drug interactions of Focalin Xr and Abilify, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Emotional distress
Gynaecomastia (enlargement of the gland tissue of the male breast)
Nausea (feeling of having an urge to vomit)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vomiting
Weight increased

10-19:

Vasospasm (sudden constriction of a blood vessel, reducing its diameter and flow rate)
Vomiting
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)
Tardive dyskinesia (a disorder that involves involuntary movements)
Drug ineffective
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dizziness
Heart rate increased
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)

20-29:

Arthralgia (joint pain)
Asthenia (weakness)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Drug abuse
Drug screen positive
Dry eye (lack of adequate tears)
Dry skin
Fatigue (feeling of tiredness)
Joint stiffness
Road traffic accident

30-39:

n/a

40-49:

Lower limb fracture
Restlessness (not able to rest)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

50-59:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dizziness
Drug withdrawal headache
Duodenogastric reflux (bile flows upward from the small intestine into the stomach)
Electrocardiogram t wave inversion
Fall
Fatigue (feeling of tiredness)
Feeding disorder (when children refuse to eat certain food groups)
Feeling of body temperature change

60+:

Drug ineffective
Initial insomnia (feeling of inadequate or poor-quality sleep)
Restlessness (not able to rest)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 13.95%
Stress And Anxiety: 4 people, 9.30%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 4 people, 9.30%
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function): 4 people, 9.30%
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 3 people, 6.98%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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