Focalin xr and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Focalin xr (dexmethylphenidate hydrochloride) and Melatonin (melatonin). Common drug interactions include pharyngitis streptococcal among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Focalin xr and Melatonin. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Focalin xr?

Focalin xr has active ingredients of dexmethylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 2,159 Focalin xr users. Check the latest studies of Focalin xr.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 12, 2026

55 people who take Focalin xr and Melatonin together, and have interactions are studied.

Focalin xr and Melatonin drug interactions.

What are the common drug interactions of Focalin Xr and Melatonin, by gender? *:

female:

Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Pigmentation disorder (disturbances of human skin colour)
Rash generalised (rash on most of body parts)
Retching (strong involuntary effort to vomit)
Vomiting
Dizziness
Drug ineffective
Hallucination (an experience involving the perception of something not present)
Impulsive behaviour
Infection

male:

Pneumonia
Pain in extremity
Drug level increased
Dyspnoea (difficult or laboured respiration)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Productive cough
Pseudomonas test positive
Red blood cell count increased
Sinusitis (inflammation of sinus)
Sputum discoloured

What are the common drug interactions of Focalin Xr and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abnormal behaviour
Hallucination (an experience involving the perception of something not present)
Abdominal discomfort
Abdominal distension
Aggression
Anxiety
Constipation
Decreased appetite
Drug ineffective
Fear

10-19:

Alanine aminotransferase increased
Blood alkaline phosphatase increased
Blood creatinine decreased
Blood urea increased
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Carbon dioxide increased
Chest discomfort
Drug level increased
Dyspnoea (difficult or laboured respiration)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

20-29:

Malaise (a feeling of general discomfort or uneasiness)
Pain in extremity
Pseudomonal bacteraemia (p. aeruginosa cause of bacterial infections of the blood)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Furuncle (infection of the hair follicle)
Pneumonia
Pruritus (severe itching of the skin)
Rash
Skin haemorrhage (bleeding into skin)
Skin ulcer

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Drug ineffective
Confusional state
Disturbance in attention
Headache (pain in head)
Impulsive behaviour
Initial insomnia (feeling of inadequate or poor-quality sleep)
Restlessness (not able to rest)

What are the existing conditions these people have? *

Sleep Disorder: 8 people, 14.55%
Wheezing (a high-pitched whistling sound made while you breath): 7 people, 12.73%
Hypersensitivity: 6 people, 10.91%
Asthma: 5 people, 9.09%
Sinus Congestion (blockage of sinus): 4 people, 7.27%
Pain: 4 people, 7.27%
Infective Pulmonary Exacerbation Of Cystic Fibrosis (severe infective lung disease with production of abnormally thick mucus): 4 people, 7.27%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.27%
Cough: 4 people, 7.27%
Bipolar Disorder (mood disorder): 4 people, 7.27%

* Approximation only. Some reports may have incomplete information.

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