Focalin and Clonazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Focalin (dexmethylphenidate hydrochloride) and Clonazepam (clonazepam). Common drug interactions include depression among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Focalin and Clonazepam. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Focalin?

Focalin has active ingredients of dexmethylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,781 Focalin users. Check the latest studies of Focalin.

What is Clonazepam?

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 146,271 Clonazepam users. Check the latest studies of Clonazepam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

72 people who take Focalin and Clonazepam together, and have interactions are studied.

Focalin and Clonazepam drug interactions.

What are the common drug interactions of Focalin and Clonazepam, by gender? *:

female:

Depression
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dizziness
Headache (pain in head)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug ineffective
Emotional disorder
Hypokinesia (decreased bodily movement)

male:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Energy increased
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Therapeutic response unexpected
Weight increased
Erythema (redness of the skin)
Joint dislocation (a joint position is changed from normal position)
Nephrolithiasis (calculi in the kidneys)
Blood pressure increased

What are the common drug interactions of Focalin and Clonazepam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Fall
Femur fracture
Influenza
Joint effusion (presence of extra fluid in joint covering)
Joint swelling
Nausea (feeling of having an urge to vomit)
Oppositional defiant disorder (a childhood disorder described by the diagnostic and statistical manual of mental disorders)
Osteomalacia (softening of the bones due to a lack of vitamin d)
Otitis media (inflammation of the middle ear)
Pain

10-19:

Aggression
Croup infectious (a loud cough that resembles the barking of a seal and difficulty breathing can transfer to other)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Cough
Mood swings (an extreme or rapid change in mood)
Sinusitis (inflammation of sinus)
Vitamin d decreased
Affect lability (emotional incontinence)
Agitation (state of anxiety or nervous excitement)
Alopecia (absence of hair from areas of the body)

20-29:

Abdominal discomfort
Diarrhoea
Nausea (feeling of having an urge to vomit)
Neuralgia (pain in one or more nerves)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Depression
Muscle spasms (muscle contraction)
Therapeutic response unexpected
Energy increased
Emotional distress

30-39:

Back injury
Blood pressure diastolic increased
Dry eye (lack of adequate tears)
Dry mouth
Dry skin
Dry throat
Headache (pain in head)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Nasal dryness (dry nose)
Pain of skin

40-49:

Bipolar disorder (mood disorder)
Cardiomyopathy (weakening of the heart muscle)
Loss of consciousness
Neck pain
Road traffic accident
Asthenia (weakness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

50-59:

Diarrhoea
Drooling (drop saliva uncontrollably from the mouth)
Dysaesthesia (abnormal sensation)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Haematocrit decreased
Haemoglobin decreased
Headache (pain in head)
Herpes zoster
Hypoaesthesia (reduced sense of touch or sensation)
Lymphocyte count decreased

60+:

Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Nausea (feeling of having an urge to vomit)
Neurodermatitis (a skin disorder characterized by long lasting itching and scratching)
Vomiting

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 20 people, 27.78%
Depression: 12 people, 16.67%
Pain: 8 people, 11.11%
High Blood Pressure: 5 people, 6.94%
Astrocytoma, Low Grade (low grade tumour of the brain that originate in a particular kind of glial-cells): 5 people, 6.94%
Neuralgia (pain in one or more nerves): 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Focalin and Clonazepam?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously