Folvite and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Folvite (folic acid) and Provigil (modafinil). Common drug interactions include abdominal tenderness among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Folvite and Provigil. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Folvite?

Folvite has active ingredients of folic acid. eHealthMe is studying from 2,529 Folvite users. Check the latest studies of Folvite.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.



On Jul, 18, 2026

19 people who take Folvite and Provigil together, and have interactions are studied.

Folvite and Provigil drug interactions.

What are the common drug interactions of Folvite and Provigil, by gender? *:

female:

  1. Abdominal tenderness
  2. Abnormal behaviour
  3. Allergy to plants
  4. Anxiety
  5. Ascites (accumulation of fluid in the abdominal cavity)
  6. Atelectasis (partial or complete collapse of the lung)
  7. Back pain
  8. Cellulitis (infection under the skin)
  9. Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
  10. Cerebral disorder (brain disease)

male:

  1. Pain
  2. Depression
  3. Arthralgia (joint pain)
  4. Atelectasis (partial or complete collapse of the lung)
  5. Balance disorder
  6. Cough
  7. Dizziness
  8. Electrocardiogram qt prolonged
  9. Haematocrit decreased
  10. Haemoglobin decreased

What are the common drug interactions of Folvite and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Hypertension (high blood pressure)
  2. Allergy to plants
  3. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  4. Constipation
  5. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  6. Depression
  7. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  8. Dizziness
  9. Dry eye (lack of adequate tears)
  10. Dyspnoea (difficult or laboured respiration)

30-39:

  1. Pneumonia
  2. Abdominal discomfort
  3. Abnormal behaviour
  4. Anxiety
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  6. Bipolar disorder (mood disorder)
  7. Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
  8. Cerebral disorder (brain disease)
  9. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  10. Confusional state

40-49:

  1. Ascites (accumulation of fluid in the abdominal cavity)
  2. Atelectasis (partial or complete collapse of the lung)
  3. Back pain
  4. Cellulitis (infection under the skin)
  5. Dyspepsia (indigestion)
  6. Fall
  7. Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
  8. Head injury
  9. Nausea (feeling of having an urge to vomit)
  10. Pancreatitis acute (sudden inflammation of pancreas)

50-59:

n/a

60+:

  1. Abdominal pain
  2. Anaemia (lack of blood)
  3. Bone marrow oedema (inflammation that causes much than the needed fluid in a bone)
  4. Bone pain
  5. Burning mouth syndrome (pain in the mouth and burning sensation on tongue)
  6. Carcinoid syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction)
  7. Carcinoid tumour of the small bowel
  8. Cellulitis (infection under the skin)
  9. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  10. Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 26.32%
  2. Drowsiness: 5 people, 26.32%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 21.05%
  4. Constipation: 3 people, 15.79%
  5. Pain: 3 people, 15.79%
  6. Depression: 3 people, 15.79%
  7. Stress And Anxiety: 2 people, 10.53%
  8. Nausea (feeling of having an urge to vomit): 2 people, 10.53%
  9. Diabetes: 2 people, 10.53%
  10. Sepsis (a severe blood infection that can lead to organ failure and death): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Folvite and Provigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Folvite:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Provigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Folvite and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Provigil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on folic acid and modafinil (the active ingredients of Folvite and Provigil, respectively), and Folvite and Provigil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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