Fragmin and Zantac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fragmin (dalteparin sodium) and Zantac (ranitidine hydrochloride). Common drug interactions include atrial fibrillation among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Fragmin and Zantac. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Fragmin?

Fragmin has active ingredients of dalteparin sodium. It is often used in deep venous thrombosis. eHealthMe is studying from 11,999 Fragmin users. Check the latest studies of Fragmin.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

On Aug, 11, 2026

93 people who take Fragmin and Zantac together, and have interactions are studied.

What are the common drug interactions of Fragmin and Zantac, by gender? *:

female:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Cardiac failure
Dyspnoea exertional (breathlessness or shortness of breath)
Epistaxis (bleed from the nose)
Febrile neutropenia (fever with reduced white blood cells)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematemesis (vomiting of blood)
Hepatic vein occlusion (blockage of the hepatic vein)
Hydronephrosis (water inside the kidney)

male:

Febrile neutropenia (fever with reduced white blood cells)
Alanine aminotransferase increased
Tonsillitis (inflammation of tonsil)
Aspartate aminotransferase increased
Collapse of lung (functional breakdown of lung)
Cystitis (inflammation of the wall of the bladder)
Dyspnoea (difficult or laboured respiration)
Gamma-glutamyltransferase increased
Headache (pain in head)
Hepatic vein occlusion (blockage of the hepatic vein)

What are the common drug interactions of Fragmin and Zantac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Acute respiratory distress syndrome
Epistaxis (bleed from the nose)
Haematemesis (vomiting of blood)
Nausea (feeling of having an urge to vomit)
Pulmonary haemorrhage (acute bleeding from the lung)
Vomiting
Blood pressure decreased
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pulmonary oedema (fluid accumulation in the lungs)

10-19:

Febrile neutropenia (fever with reduced white blood cells)
Hepatic vein occlusion (blockage of the hepatic vein)
Alanine aminotransferase increased
Anaemia (lack of blood)
Arrhythmia (irregular heartbeat)
Cardiac failure
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hyperglycaemia (high blood sugar)
Hypoaesthesia (reduced sense of touch or sensation)

20-29:

Drug hypersensitivity
Tonsillitis (inflammation of tonsil)
Urinary tract infection
Cystitis (inflammation of the wall of the bladder)
Febrile neutropenia (fever with reduced white blood cells)
Neutropenia (an abnormally low number of neutrophils)
Headache (pain in head)

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Gamma-glutamyltransferase increased
Blood lactate dehydrogenase increased
Blood alkaline phosphatase nos increased
Delivery
Drug exposure during pregnancy
Right ventricular failure (right half of the heart fails to work)

40-49:

Myalgia (muscle pain)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Chest pain
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Diarrhoea
Disease progression
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)

50-59:

Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Thrombocythaemia (an increased number of platelets in the circulating blood)
Thrombosis (formation of a blood clot inside a blood vessel)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Dyspnoea (difficult or laboured respiration)
Pelvic pain
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pyrexia (fever)
Constipation
Hypercalcaemia (elevated calcium (ca+) level in the blood)

60+:

Impaired healing
Postoperative wound complication
Muscular weakness (muscle weakness)
Pain
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Upper respiratory tract infection
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure diastolic increased

What are the existing conditions these people have? *

Pain: 16 people, 17.20%
Indigestion: 11 people, 11.83%
Sedation: 10 people, 10.75%
High Blood Pressure: 8 people, 8.60%
Traumatic Haemorrhage (a bleeding due to trauma): 7 people, 7.53%
Nausea (feeling of having an urge to vomit): 7 people, 7.53%
Immunodeficiency Disorders: 6 people, 6.45%
Constipation: 6 people, 6.45%
Transitional Cell Carcinoma (cancer tumour inner most layer of urinary system): 5 people, 5.38%
Skin Ulcer: 5 people, 5.38%

* Approximation only. Some reports may have incomplete information.

Do you take Fragmin and Zantac?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously