Gabapentin and Methylene blue drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gabapentin (gabapentin) and Methylene blue (methylene blue). Common drug interactions include embolism among females and serotonin syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Gabapentin and Methylene blue. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Gabapentin?

Gabapentin has active ingredients of gabapentin. It is often used in neuralgia. eHealthMe is studying from 322,983 Gabapentin users. Check the latest studies of Gabapentin.

What is Methylene blue?

Methylene blue has active ingredients of methylene blue. eHealthMe is studying from 1,061 Methylene blue users. Check the latest studies of Methylene blue.

On Jul, 09, 2026

39 people who take Gabapentin and Methylene blue together, and have interactions are studied.

Gabapentin and Methylene blue drug interactions.

What are the common drug interactions of Gabapentin and Methylene Blue, by gender? *:

female:

Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Coma (state of unconsciousness lasting more than six hours)
Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Dry mouth
Cardiogenic shock (inadequate circulation of blood)

male:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Agitation (state of anxiety or nervous excitement)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Lactic acidosis (low ph in body tissues)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
Depressed level of consciousness
Depression
Drug ineffective
Haemodynamic instability (disturbances in the blood movement in our body)

What are the common drug interactions of Gabapentin and Methylene Blue, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Epistaxis (bleed from the nose)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Renal tubular disorder (disease of kidney tubules)

20-29:

n/a

30-39:

n/a

40-49:

Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Overdose

50-59:

Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Brain injury
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Lactic acidosis (low ph in body tissues)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Blood parathyroid hormone decreased

60+:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Hyperhidrosis (abnormally increased sweating)
Insomnia (sleeplessness)
Tremor (trembling or shaking movements in one or more parts of your body)
Cardiogenic shock (inadequate circulation of blood)
Dry mouth
Dysphagia (a condition in which swallowing is difficult or painful)
Energy increased
Fungal infection

What are the existing conditions these people have? *

Vasoplegia Syndrome (low systemic vascular resistance): 16 people, 41.03%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 12 people, 30.77%
High Blood Pressure: 8 people, 20.51%
Insomnia (sleeplessness): 7 people, 17.95%
Alanine Aminotransferase Increased: 6 people, 15.38%
Anaemia (lack of blood): 6 people, 15.38%
Aspartate Aminotransferase Increased: 6 people, 15.38%
Constipation: 6 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 15.38%
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 6 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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