Gablofen and Lexapro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gablofen (baclofen) and Lexapro (escitalopram oxalate). Common drug interactions include cerebrospinal fluid leakage among females and muscle spasms among males.

The phase IV clinical study analyzes what interactions people have when they take Gablofen and Lexapro. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Gablofen?

Gablofen has active ingredients of baclofen. eHealthMe is studying from 3,044 Gablofen users. Check the latest studies of Gablofen.

What is Lexapro?

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,464 Lexapro users. Check the latest studies of Lexapro.

On Jul, 21, 2026

18 people who take Gablofen and Lexapro together, and have interactions are studied.

What are the common drug interactions of Gablofen and Lexapro, by gender? *:

female:

Cerebrospinal fluid leakage
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Acne (skin problems that cause pimples)
Anger
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Decreased appetite
Mood swings (an extreme or rapid change in mood)
Weight decreased
Agitation (state of anxiety or nervous excitement)
Device failure

male:

Muscle spasms (muscle contraction)
Agitation (state of anxiety or nervous excitement)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Staphylococcus test positive
Wheezing (a high-pitched whistling sound made while you breath)
Arrhythmia (irregular heartbeat)
Bacteraemia (presence of bacteria in the blood)
Hypertension (high blood pressure)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Influenza

What are the common drug interactions of Gablofen and Lexapro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypotension (abnormally low blood pressure)
Muscle spasms (muscle contraction)
Muscle tightness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pruritus (severe itching of the skin)

20-29:

Abdominal discomfort
Agitation (state of anxiety or nervous excitement)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Discomfort
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Gait disturbance
Hyperhidrosis (abnormally increased sweating)
Implant site infection
Muscle spasms (muscle contraction)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)

30-39:

n/a

40-49:

Cerebrospinal fluid leakage
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Agitation (state of anxiety or nervous excitement)
Device failure
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Muscle rigidity (muscle stiffness)
Muscle spasms (muscle contraction)
Pruritus (severe itching of the skin)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

50-59:

Agitation (state of anxiety or nervous excitement)
Arrhythmia (irregular heartbeat)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)
Urinary tract infection
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Bacteraemia (presence of bacteria in the blood)
Hypertension (high blood pressure)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)

60+:

n/a

What are the existing conditions these people have? *

Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 15 people, 83.33%
Cerebral Palsy: 2 people, 11.11%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 5.56%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.56%
Muscle Tightness: 1 person, 5.56%
Muscle Spasms (muscle contraction): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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