Gilenya and Combivent drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Gilenya (fingolimod) and Combivent (albuterol sulfate; ipratropium bromide). Common drug interactions include hypokalaemia among females and diabetes mellitus among males.
The phase IV clinical study analyzes what interactions people have when they take Gilenya and Combivent. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.
What is Gilenya?
Gilenya has active ingredients of fingolimod. It is often used in multiple sclerosis. eHealthMe is studying from 111,893 Gilenya users. Check the latest studies of Gilenya.
What is Combivent?
Combivent has active ingredients of albuterol sulfate; ipratropium bromide. It is often used in asthma. eHealthMe is studying from 35,341 Combivent users. Check the latest studies of Combivent.
24 people who take Gilenya and Combivent together, and have interactions are studied.

What are the common drug interactions of Gilenya and Combivent, by gender? *:
female:
- Hypokalaemia (low potassium)
- Infusion site swelling
- Infusion site thrombosis
- Injection site bruising
- Joint swelling
- Lung infection
- Neuropathy peripheral (surface nerve damage)
- Pain
- Pneumonia
- Rash
male:
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Angioedema (rapid swelling of the dermis)
- Dysphagia (a condition in which swallowing is difficult or painful)
- Dyspnoea (difficult or laboured respiration)
- Epistaxis (bleed from the nose)
- Eyelid ptosis (falling of the upper or lower eyelid)
- Fatigue (feeling of tiredness)
- Gait disturbance
- Heart rate decreased
- Hypertension (high blood pressure)
What are the common drug interactions of Gilenya and Combivent, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Infusion site thrombosis
- Injection site bruising
- Joint swelling
- Oedema peripheral (superficial swelling)
- Pain
- Pneumonia
- Rash
- Asthenia (weakness)
- Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
- Chest discomfort
40-49:
n/a
50-59:
- Weight increased
- Cough
- Diarrhoea
- Ear infection
- Fall
- Fatigue (feeling of tiredness)
- Hypoaesthesia (reduced sense of touch or sensation)
- Increased appetite
- Nasopharyngitis (inflammation of the nasopharynx)
- Nausea (feeling of having an urge to vomit)
60+:
- Dyspnoea (difficult or laboured respiration)
- Oedema peripheral (superficial swelling)
- Red cell distribution width increased
- Arteriosclerosis (thickening and hardening of arteries)
- Chest discomfort
- Chest pain
- Glomerular filtration rate decreased
- Glomerulonephritis rapidly progressive (a syndrome of the kidney that is characterized by a rapid loss of renal function)
- Hyperhidrosis (abnormally increased sweating)
- Kidney fibrosis (excess fibrous connective tissue in kidney)
What are the existing conditions these people have? *
- Wheezing (a high-pitched whistling sound made while you breath): 3 people, 12.50%
- Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 3 people, 12.50%
- Hypersensitivity: 3 people, 12.50%
- High Blood Cholesterol: 3 people, 12.50%
- Bowel Movement Irregularity: 3 people, 12.50%
* Approximation only. Some reports may have incomplete information.
Do you take Gilenya and Combivent?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Gilenya and Combivent:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Gilenya:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Combivent:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Gilenya and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Combivent and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
- Alroughani R, "Fingolimod-associated amenorrhea: a report of three cases", Multiple Sclerosis Journal, 2014 Jan .
- Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .
- Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
- Alroughani R, "Fingolimod-associated amenorrhea: a report of three cases", Multiple Sclerosis Journal, 2014 Jan .
- Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on fingolimod and albuterol sulfate; ipratropium bromide (the active ingredients of Gilenya and Combivent, respectively), and Gilenya and Combivent (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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