Gleevec and Amitiza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gleevec (imatinib mesylate) and Amitiza (lubiprostone). Common drug interactions include hypotension among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Gleevec and Amitiza. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Gleevec?

Gleevec has active ingredients of imatinib mesylate. It is often used in chronic myelogenous leukemia (cml). eHealthMe is studying from 35,415 Gleevec users. Check the latest studies of Gleevec.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

On Jul, 27, 2026

13 people who take Gleevec and Amitiza together, and have interactions are studied.

What are the common drug interactions of Gleevec and Amitiza, by gender? *:

female:

Hypotension (abnormally low blood pressure)
Iron deficiency anaemia
Joint swelling
Lethargy (tiredness)
Leukocytosis (increased white blood cells)
Leukopenia (less number of white blood cells in blood)
Malaise (a feeling of general discomfort or uneasiness)
Mastoiditis (infection of mastoid bone)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Micturition urgency (urgency to pass the urine)

male:

Nausea (feeling of having an urge to vomit)
Back pain
Metastases to lung (cancer spreads to lung)
Metastases to lymph nodes (cancer spreads to lymph node)
Pyrexia (fever)
Spinal compression fracture (fracture due to spinal compression on bone)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vomiting
Weight decreased
Abdominal distension

What are the common drug interactions of Gleevec and Amitiza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Eye haemorrhage (bleeding in the eye)
Eye swelling

60+:

Nausea (feeling of having an urge to vomit)
Diarrhoea
Metastases to bone (cancer spreads to bone)
Metastases to liver (cancer spreads to liver)
Metastases to lung (cancer spreads to lung)
Metastases to lymph nodes (cancer spreads to lymph node)
Pyrexia (fever)
Spinal compression fracture (fracture due to spinal compression on bone)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Weight decreased

What are the existing conditions these people have? *

Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 11 people, 84.62%
Polymyalgia Rheumatica (pain in many muscles): 1 person, 7.69%
Gastrointestinal Stromal Tumor: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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