Gleevec and Centrum silver drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Gleevec (imatinib mesylate) and Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include red blood cell sedimentation rate increased among females and anaemia among males.
The phase IV clinical study analyzes what interactions people have when they take Gleevec and Centrum silver. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.
What is Gleevec?
Gleevec has active ingredients of imatinib mesylate. It is often used in chronic myelogenous leukemia (cml). eHealthMe is studying from 35,415 Gleevec users. Check the latest studies of Gleevec.
What is Centrum silver?
Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.
51 people who take Gleevec and Centrum silver together, and have interactions are studied.

What are the common drug interactions of Gleevec and Centrum Silver, by gender? *:
female:
- Red blood cell sedimentation rate increased
- Joint swelling
- Arthralgia (joint pain)
- Breast cancer
- Death
- Osteonecrosis (death of bone)
- Pain in extremity
- Conjunctival oedema (conjunctival swelling)
- Conjunctivitis (pink eye)
- Dyspnoea exertional (breathlessness or shortness of breath)
male:
- Anaemia (lack of blood)
- Fall
- Pain
- Pericardial effusion (fluid around the heart)
- Pleural effusion (water on the lungs)
- Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
- Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
- Red blood cell count decreased
- Syncope (loss of consciousness with an inability to maintain postural tone)
- Thrombocytopenia (decrease of platelets in blood)
What are the common drug interactions of Gleevec and Centrum Silver, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Lumbar vertebral fracture
- Pain
- Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
- Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
- Syncope (loss of consciousness with an inability to maintain postural tone)
- Thrombocytopenia (decrease of platelets in blood)
- Arthralgia (joint pain)
- Eye swelling
- Fluid retention (an abnormal accumulation of fluid in the blood)
- Oedema peripheral (superficial swelling)
60+:
- Oedema peripheral (superficial swelling)
- Nausea (feeling of having an urge to vomit)
- Red blood cell count decreased
- Weight decreased
- Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
- Colon cancer
- Constipation
- Death
- Diarrhoea
- Dizziness
What are the existing conditions these people have? *
- Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 15 people, 29.41%
- Gastrointestinal Stromal Tumor: 12 people, 23.53%
- Neoplasm Malignant (cancer tumour): 8 people, 15.69%
- Pain: 3 people, 5.88%
- Leukaemia (blood or bone marrow cancer): 3 people, 5.88%
* Approximation only. Some reports may have incomplete information.
Do you take Gleevec and Centrum silver?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Gleevec (35,415 reports)
- Centrum silver (19,997 reports)
Browse all drug interactions of Gleevec and Centrum silver:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Gleevec:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Centrum silver:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Gleevec and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Centrum silver and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- O'rafferty C, McElligott F, Storey L, O'marcaigh A, Smith O, "Pneumatosis intestinalis and imatinib mesylate", Annals of hematology, 2014 Oct .
- O'rafferty C, McElligott F, Storey L, O'marcaigh A, Smith O, "Pneumatosis intestinalis and imatinib mesylate", Annals of hematology, 2014 Oct .
How the study uses the data?
The study uses data from the FDA. It is based on imatinib mesylate and ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Gleevec and Centrum silver, respectively), and Gleevec and Centrum silver (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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