Gleevec and Lactulose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gleevec (imatinib mesylate) and Lactulose (lactulose). Common drug interactions include aspartate aminotransferase increased among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Gleevec and Lactulose. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Gleevec?

Gleevec has active ingredients of imatinib mesylate. It is often used in chronic myelogenous leukemia (cml). eHealthMe is studying from 35,415 Gleevec users. Check the latest studies of Gleevec.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

On Jul, 19, 2026

37 people who take Gleevec and Lactulose together, and have interactions are studied.

Gleevec and Lactulose drug interactions.

What are the common drug interactions of Gleevec and Lactulose, by gender? *:

female:

Aspartate aminotransferase increased
Back pain
Blood bilirubin increased
Blood culture positive
Cardiac failure
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Fluid overload (too much fluid in the blood)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hepatic failure (liver failure)
Implant infection (infection at implant site)

male:

Diarrhoea
Vomiting
Early satiety (feeling full before completing a normal sized meal)
Hypertension (high blood pressure)
Lumbar vertebral fracture
Metastases to adrenals (cancer spreads to adrenal gland of kidney)
Metastases to bone (cancer spreads to bone)
Metastases to lung (cancer spreads to lung)
Metastases to lymph nodes (cancer spreads to lymph node)
Spinal compression fracture (fracture due to spinal compression on bone)

What are the common drug interactions of Gleevec and Lactulose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Anaemia (lack of blood)
Aspartate aminotransferase increased
Back pain
Blood bilirubin increased
Blood culture positive
Cardiac failure
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Fluid overload (too much fluid in the blood)
Implant infection (infection at implant site)

30-39:

Gastrointestinal fistula (an abnormal opening that allows the contents of the stomach or intestines to leak)
Impaired healing
Intestinal perforation (complete penetration of the wall of the intestine)

40-49:

Gastric cancer (stomach cancer)
Ascites (accumulation of fluid in the abdominal cavity)
Back pain
Blood magnesium decreased
Cholangitis (infection of the bile duct)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Death
Diarrhoea
Fluid retention (an abnormal accumulation of fluid in the blood)
Hepatic failure (liver failure)

50-59:

Confusional state
Death
Dehydration (dryness resulting from the removal of water)
Dental caries
Depression
Dermal cyst
Dysuria (painful or difficult urination)
Gingival disorder (gum disease)
Hypoxic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Impaired gastric emptying

60+:

Vomiting
Metastases to liver (cancer spreads to liver)
Lumbar vertebral fracture
Metastases to adrenals (cancer spreads to adrenal gland of kidney)
Metastases to bone (cancer spreads to bone)
Metastases to lung (cancer spreads to lung)
Metastases to lymph nodes (cancer spreads to lymph node)
Pyrexia (fever)
Spinal compression fracture (fracture due to spinal compression on bone)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the existing conditions these people have? *

Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 14 people, 37.84%
Pain: 4 people, 10.81%
Gastrointestinal Stromal Tumor: 4 people, 10.81%
Nausea (feeling of having an urge to vomit): 3 people, 8.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.11%
Neoplasm Malignant (cancer tumour): 2 people, 5.41%
Kidney Fibrosis (excess fibrous connective tissue in kidney): 2 people, 5.41%
Indigestion: 2 people, 5.41%
High Blood Pressure: 2 people, 5.41%
Depression: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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