Gleevec and Xarelto drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gleevec (imatinib mesylate) and Xarelto (rivaroxaban). Common drug interactions include dyspnoea among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Gleevec and Xarelto. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Gleevec?

Gleevec has active ingredients of imatinib mesylate. It is often used in chronic myelogenous leukemia (cml). eHealthMe is studying from 35,415 Gleevec users. Check the latest studies of Gleevec.

What is Xarelto?

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 212,377 Xarelto users. Check the latest studies of Xarelto.

On Jul, 13, 2026

80 people who take Gleevec and Xarelto together, and have interactions are studied.

What are the common drug interactions of Gleevec and Xarelto, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Eye haemorrhage (bleeding in the eye)
Fatigue (feeling of tiredness)
Haemoglobin decreased
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Laziness
Lip injury
Memory impairment
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Diarrhoea
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Cardiac failure congestive
Renal failure (kidney dysfunction)
Arteritis (inflammation of the walls of arteries)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Infection
Pain in extremity
Arthritis (form of joint disorder that involves inflammation of one or more joints)

What are the common drug interactions of Gleevec and Xarelto, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Disease progression

10-19:

n/a

20-29:

Drug ineffective
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Injection site erythema (redness at injection site)
Intestinal haemorrhage (bleeding from intestine)
Nausea (feeling of having an urge to vomit)
Vomiting
White blood cell count increased

30-39:

n/a

40-49:

n/a

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Infection
Joint injury
Sepsis (a severe blood infection that can lead to organ failure and death)
Epistaxis (bleed from the nose)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemorrhage (bleeding)
Rectal haemorrhage (bleeding from anus)
Influenza
Pain

60+:

Dyspnoea (difficult or laboured respiration)
Cough
Atrophic glossitis (smooth tongue)
Blood potassium increased
Blood pressure increased
Bone density decreased
Burning sensation
Cardiac flutter (abnormal heart rhythm)
Chills (felling of cold)
Coagulopathy (blood's ability to clot is impaired)

What are the existing conditions these people have? *

Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 38 people, 47.50%
Vitamin B12 Deficiency: 15 people, 18.75%
Folate Deficiency (lack of folic acid): 15 people, 18.75%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 14 people, 17.50%
Neoplasm Malignant (cancer tumour): 9 people, 11.25%
Cardiac Disorder: 8 people, 10.00%
Wheezing (a high-pitched whistling sound made while you breath): 6 people, 7.50%
Gastrointestinal Stromal Tumor: 6 people, 7.50%
Dyspnea (difficult or laboured breathing): 6 people, 7.50%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 6 people, 7.50%

* Approximation only. Some reports may have incomplete information.

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