Glimepiride and Sumatriptan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glimepiride (glimepiride) and Sumatriptan (sumatriptan succinate). Common drug interactions include perirectal abscess among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Glimepiride and Sumatriptan. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Glimepiride?

Glimepiride has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 45,909 Glimepiride users. Check the latest studies of Glimepiride.

What is Sumatriptan?

Sumatriptan has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 18,159 Sumatriptan users. Check the latest studies of Sumatriptan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

48 people who take Glimepiride and Sumatriptan together, and have interactions are studied.

Glimepiride and Sumatriptan drug interactions.

What are the common drug interactions of Glimepiride and Sumatriptan, by gender? *:

female:

Perirectal abscess
Platelet count decreased
Pleural effusion (water on the lungs)
Red blood cell count decreased
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Chronic kidney disease
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Splenomegaly (enlargement of spleen)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Back pain
Blood creatinine increased
Emotional distress

What are the common drug interactions of Glimepiride and Sumatriptan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Renal injury (kidney injury)
Tooth abscess (pus formation in tooth)
Chronic kidney disease
Anxiety
Anal abscess
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Back pain
Blood creatinine increased
Emotional distress
Gastritis (inflammation of stomach)

50-59:

Chronic kidney disease
Depression
Renal failure (kidney dysfunction)
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Feeling hot
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Cardiomegaly (increased size of heart than normal)
Diarrhoea
Hyperbilirubinaemia (excess of bilirubin in the blood)

60+:

Anaemia (lack of blood)
Chordoma (a brain tumour from the embryo)
Adverse drug reaction
Anxiety
Asthma
Blood glucose increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depressed mood
Depression
Drug ineffective

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 22.92%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 18.75%
Type 2 Diabetes: 7 people, 14.58%
High Blood Cholesterol: 6 people, 12.50%
Stress And Anxiety: 6 people, 12.50%
Hypersensitivity: 5 people, 10.42%
Nausea (feeling of having an urge to vomit): 5 people, 10.42%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 10.42%
Diarrhea: 4 people, 8.33%
Fungal Infection: 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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