Glucagon and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucagon (glucagon hydrochloride) and Methotrexate (methotrexate sodium). Common drug interactions include renal injury among females and infection among males.

The phase IV clinical study analyzes what interactions people have when they take Glucagon and Methotrexate. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Glucagon?

Glucagon has active ingredients of glucagon hydrochloride. eHealthMe is studying from 4,297 Glucagon users. Check the latest studies of Glucagon.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

58 people who take Glucagon and Methotrexate together, and have interactions are studied.

Glucagon and Methotrexate drug interactions.

What are the common drug interactions of Glucagon and Methotrexate, by gender? *:

female:

Renal injury (kidney injury)
Urinary tract infection
Acute leukaemia (blood cancer)
Cholangitis (infection of the bile duct)
Cold sweat
Contusion (a type of hematoma of tissue in which capillaries)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diarrhoea

male:

Infection
Asthenia (weakness)
Vomiting
Actinomycosis (infection that causes sores, or abscesses)
Clostridial infection (infectious conditions by clostridium bacteria)
Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina)
Platelet count decreased
Staphylococcal infection (an infection with staphylococcus bacteria)
Systemic candida (whole body fungal infection)
Abdominal pain

What are the common drug interactions of Glucagon and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug ineffective
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Infection
Febrile neutropenia (fever with reduced white blood cells)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

10-19:

Blood glucose increased
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Dyspnoea (difficult or laboured respiration)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abdominal pain
Blood phosphorus increased
Blood potassium decreased
Lactic acidosis (low ph in body tissues)
Pancreatitis acute (sudden inflammation of pancreas)

20-29:

Abdominal pain
Abdominal pain upper
Acute leukaemia (blood cancer)
Bacteraemia (presence of bacteria in the blood)
Chills (felling of cold)
Dyspnoea exertional (breathlessness or shortness of breath)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Overdose
Pleuritic pain

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Anaemia of chronic disease
Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Hepatic lesion
Infusion related reaction
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)

40-49:

Cholangitis (infection of the bile duct)
Cough
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Infection
Influenza
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Oxygen saturation decreased

50-59:

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Malaise (a feeling of general discomfort or uneasiness)
Restless legs syndrome (a powerful urge to move your legs)
Nausea (feeling of having an urge to vomit)
Pain
Arthralgia (joint pain)
Hyperhidrosis (abnormally increased sweating)
Muscular weakness (muscle weakness)
Nervousness
Night sweats (sweating in night)

60+:

Acute respiratory distress syndrome
Embolic stroke (stroke due to obstruction due to an embolus)
Injection site irritation
Prostatic specific antigen increased
Actinomycosis (infection that causes sores, or abscesses)
Asthenia (weakness)
Clostridial infection (infectious conditions by clostridium bacteria)
Hepatorenal failure (decrease in kidney function in a person with a severe liver disorder)
Infection
Mobility decreased (ability to move is reduced)

What are the existing conditions these people have? *

Pain: 17 people, 29.31%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 20.69%
Stress And Anxiety: 11 people, 18.97%
Depression: 10 people, 17.24%
Muscle Spasms (muscle contraction): 10 people, 17.24%
Diabetes: 9 people, 15.52%
Nausea (feeling of having an urge to vomit): 9 people, 15.52%
Hypoglycemia (low blood sugar): 9 people, 15.52%
Nausea And Vomiting: 8 people, 13.79%
Wheezing (a high-pitched whistling sound made while you breath): 7 people, 12.07%

* Approximation only. Some reports may have incomplete information.

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