Glucophage and Keytruda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucophage (metformin hydrochloride) and Keytruda (pembrolizumab). Common drug interactions include fluid intake reduced among females and pneumonitis among males.

The phase IV clinical study analyzes what interactions people have when they take Glucophage and Keytruda. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

On Jul, 17, 2026

35 people who take Glucophage and Keytruda together, and have interactions are studied.

Glucophage and Keytruda drug interactions.

What are the common drug interactions of Glucophage and Keytruda, by gender? *:

female:

Fluid intake reduced
Hyperglycaemia (high blood sugar)
Hyperosmolar state (life-threatening emergency manifested by marked elevation of blood glucose)
Hypersomnia (excessive daytime sleepiness (eds))
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lymphadenopathy (disease or enlargement of lymph nodes)
Mass
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

male:

Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Fatigue (feeling of tiredness)
Pyrexia (fever)
Vomiting
Weight decreased
Autoimmune myocarditis (inflammation of the heart muscle by immune system disorder)
Confusional state
Death
Malignant neoplasm progression (cancer tumour came back)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

What are the common drug interactions of Glucophage and Keytruda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood urea increased
Chills (felling of cold)
Cough
Device related infection
Diabetes mellitus inadequate control
Discomfort
Drug hypersensitivity
Dry mouth
Dysuria (painful or difficult urination)
Fall

50-59:

Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Fatigue (feeling of tiredness)
Pain
Pyrexia (fever)
Red blood cell count decreased
Vomiting
Blood albumin decreased
Blood creatinine increased
Blood glucose increased
Blood urea increased

60+:

Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Confusional state
Death
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Obstruction gastric (obstruction in stomach)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Angioedema (rapid swelling of the dermis)
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 9 people, 25.71%
White Blood Cells Urine Positive: 6 people, 17.14%
Urination - Painful: 6 people, 17.14%
Stress And Anxiety: 6 people, 17.14%
Ovarian Cancer (cancer of ovary): 6 people, 17.14%
Malignant Melanoma (skin cancer rises from melancytes): 4 people, 11.43%
Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 5.71%
Peripheral T-Cell Lymphoma Unspecified (peripheral t-cell cancer unspecified): 2 people, 5.71%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 2 people, 5.71%
Heart Disease: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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